Evidence map›Paper›PMID 35155249›Full record

ArticleFrontiers in oncology2022

Neutrophils Promote Tumor Progression in Oral Squamous Cell Carcinoma by Regulating EMT and JAK2/STAT3 Signaling Through Chemerin.

Xiaoyuan Hu, Fenggang Xiang, Yuanyong Feng, Fei Gao, Shengyou Ge, Chengqin Wang, Xuan Zhang, Ning Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 43 citations in OpenAlex.

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  14. [Mechanism ofSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
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  16. Neutrophils: emerging perspectives on the pathogenesis of oral mucosal diseases.Frontiers in cellular and infection microbiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaoyuan HuDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Fenggang XiangDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Yuanyong FengDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Fei GaoDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Shengyou GeDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Chengqin WangDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Xuan ZhangDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Ning WangDepartment of Pathology, School of Basic Medicine, Medical College of Qingdao University, Qingdao, China.
Qingdao University · CNAffiliated Hospital of Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. In the tumor microenvironment, tumor-associated neutrophils (TANs) can promote tumor growth, invasion, and metastasis. The aim of our study was to explore the relationship between neutrophils infiltration and Chemerin expression in tumor cells, as well as their relationship with the clinicopathological parameters and clinical prognosis of 74 cases of OSCC. We also explored the role of the interaction between neutrophils and Chemerin in the functions of OSCC cells (Cal27, SCC9, and SCC15)

Indexed as

chemerinEMTJAK2/STAT3neutrophilsoral squamous cell carcinomatumor progression

Identifiers

PMID35155249
PMCPMC8831747
OpenAlexW4210246334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.