ReviewFrontiers in oncology2022
Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases.
Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Beyond SINS: A Critical Review of Biomechanical, Microstructural, and Radiomic Biomarkers for Predicting Fracture Risk in Spinal Metastases.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical Outcomes of Surgery Versus Radiotherapy in Bilsky Grade 3 Metastatic Epidural Spinal Cord Compression.Journal of clinical medicine · 2025Article
- Clinical considerations for non-operative treatment of spinal metastases with intermediate instability.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Advances in Radiotherapy in the Treatment of Metastatic Spinal Lesions.Revista brasileira de ortopedia · 2025Article
- [Advances in Radiotherapy in the Treatment of Metastatic Spinal Lesions].Revista brasileira de ortopedia · 2025Article
- A critical appraisal of clinical guidelines on radiotherapy treatments for spinal metastasis.Neurosurgical review · 2025Review
- Poroelastic Characterization of Human Vertebral Metastases to Inform a Transdisciplinary Assessment of Spinal Tumors.Journal of clinical medicine · 2025Article
- Current Concepts in the Management and Treatment of Spinal Metastases-A Systematic Literature Review.Cancers · 2025Review
- Impact of Personalized Recovery Interventions on Spinal Instability and Psychological Distress in Oncological Patients with Vertebral Metastases.Diseases (Basel, Switzerland) · 2025Article
- Radiotherapy and surgery: can this combination be further optimized for patients with metastatic spine disease?The oncologist · 2025Review
- Treatment Outcomes in Spinal Tumors According to Patients' Perspectives: A Focus on Indeterminate Spinal Instability.Current oncology (Toronto, Ont.) · 2025Article
- Prevention and Management of Posterior Wound Complications Following Oncologic Spine Surgery: Narrative Review of Available Evidence and Proposed Clinical Decision-Making Algorithm.Global spine journal · 2025Article
- Review
- Article
- Imaging of Multiple Myeloma: Present and Future.Journal of clinical medicine · 2024Review
- Enhancing the referral process for surgical management of spinal metastases: insights from a 12-year, bi-institutional study of 533 patients.Frontiers in oncology · 2024Article
- Review
- Vertebral body collapse after radiotherapy for spinal metastases.Oncology letters · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the different types of treatments for a spinal metastasis is to provide the best oncological and functional result with the least aggressive side effects. Initially created in 2010 to help clinicians in the management of vertebral metastases, the Spine Instability Neoplastic Score (SINS) has quickly found its place in the decision making and the treatment of patients with metastatic spinal disease. Here we conduct a review of the literature describing the different changes that occurred with the SINS score in the last ten years. After a brief presentation of the spinal metastases' distribution, with or without spinal cord compression, we present the utility of SINS in the radiological diagnosis and extension of the disease, in addition to its limits, especially for scores ranging between 7 and 12. We take this opportunity to expose the latest advances in surgery and radiotherapy concerning spinal metastases, as well as in palliative care and pain control. We also discuss the reliability of SINS amongst radiologists, radiation oncologists, spine surgeons and spine surgery trainees. Finally, we will present the new SINS-derived predictive scores, biomarkers and artificial intelligence algorithms that allow a multidisciplinary approach for the management of spinal metastases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.