Evidence map›Paper›PMID 35155212›Full record

ArticleFrontiers in oncology2021

Preoperative Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Predict Survival Outcomes of Patients With Hepatocellular Carcinoma After Curative Resection.

Zhen Qu, Yun-Jie Lu, Jia-Wei Feng, Yu-Xiang Chen, Long-Qing Shi, Jing Chen, Navin Rambaran, Yun-Fei Duan, Xiao-Zhou He

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In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhen QuThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.
Yun-Jie LuThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.
Jia-Wei FengThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.
Yu-Xiang ChenThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.
Long-Qing ShiThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.
Jing ChenThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.
Navin RambaranDepartment of General Surgery, Georgetown Hospital Complex, Georgetown, Guyana.
Yun-Fei DuanThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.
Xiao-Zhou HeThe Third Affiliated Hospital of Soochow University, Changzhou First People's Hospital, Changzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence indicates that preoperative prognostic indices can serve as independent predictors of survival in patients with cancer. However, the applicability of these indices in patients with hepatocellular carcinoma (HCC) is controversial. This study aims to investigate the prognostic value of these indices in patients with HCC after curative hepatectomy. We retrospectively analyzed the data of 215 patients who underwent curative resection for HCC. Prognostic indices including prognostic nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) were evaluated by comparing by the area under the curve (AUC). Univariate analysis and multivariate analysis were performed to identify independent prognostic factors. Additionally, risk factors were combined to predict the survival of patients. We found that serum albumin concentration, tumor diameter, tumor stage, degree of differentiation, PNI, and NLR were independent prognostic factors for overall survival (OS). Vascular invasion, tumor stage, degree of differentiation, and PNI were independent prognostic factors for recurrence-free survival (RFS). The cutoff value of the PNI and NLR was 43.75 and 3.29, respectively. Patients with low NLR and high PNI had the best outcomes, potentially indicative of the intensive antitumor effects of the immune system. Moreover, patients with at least three risk factors had a significantly lower OS and RFS compared with those with two or fewer risk factors. This new nomogram based on PNI and NLR may provide an accessible and individualized prediction of survival and recurrence for HCC patients.

Indexed as

hepatocellular carcinomaneutrophil-to-lymphocyte ratioprognostic factorsprognostic nutrition indexsurvival

Identifiers

PMID35155212
PMCPMC8831760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.