Evidence map›Paper›PMID 35155125›Full record

ArticleIDCases2022

Intravenous veterinary ivermectin in a COVID-19 patient causing neurotoxicity.

Stefan Porubcin, Alena Rovnakova, Ondrej Zahornacky, Pavol Jarcuska

Abstract readCase Reports
In one paragraph

Article in IDCases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stefan PorubcinThe Department of Infectious Diseases and Travel Medicine, Louis Pasteur University Hospital, Rastislavova 43, Kosice 04011, Slovakia.
Alena RovnakovaThe Department of Infectious Diseases and Travel Medicine, Louis Pasteur University Hospital, Rastislavova 43, Kosice 04011, Slovakia.
Ondrej ZahornackyThe Department of Infectious Diseases and Travel Medicine, Louis Pasteur University Hospital, Rastislavova 43, Kosice 04011, Slovakia.
Pavol JarcuskaThe Department of Infectious Diseases and Travel Medicine, Louis Pasteur University Hospital, Rastislavova 43, Kosice 04011, Slovakia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ivermectin administration for Coronavirus disease 2019 (COVID-19) infection has gained a lot of attention recently. Although ivermectin has a relatively good safety profile, serious adverse events may occur in patients given doses that are presumed experimental. Ivermectin for human use is available only as an oral formulation. Parenteral administration, as a subcutaneous injection, is possible in veterinary medicine only. In this brief report we describe an unprecedented case of a patient with severe neurotoxicity after intravenous administration of veterinary ivermectin for confirmed COVID-19 infection. The patient required hospitalization in the intensive care unit (ICU). The toxic serum concentration of ivermectin was determined by liquid chromatography/mass spectrometry - time of flight (LC/MS-TOF) with the value of 187.74 ng/mL.

Indexed as

COVID-19IvermectinNeurotoxicity

Identifiers

PMID35155125
PMCPMC8818555

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.