ArticleBiomedical optics express2022
Optically computed phase microscopy for quantitative dynamic imaging of label-free cells and nanoparticles.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Modulated Doppler phase microscopy for dynamic imaging with subcellular resolution.Biomedical optics express · 2026Article
- Phase-augmented deep learning for cell segmentation in wrapped quantitative phase images.Biomedical optics express · 2025Article
- Imaging cells and nanoparticles using modulated optically computed phase microscopy.Scientific reports · 2025Article
- Complex optically computed phase microscopy for label-free sub-cellular imaging.Optics continuum · 2023Article
- Label-free full-field Doppler phase microscopy based on optical computation.Biomedical optics express · 2023Article
- Quantitative dynamic cellular imaging based on 3D unwrapped optically computed phase microscopy.Applied optics · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Numerous drug delivery systems based on nanoparticles have been developed, such as those used in BioNTech/Pfizer's and Moderna's Covid vaccines. Knowledge on mechanical interactions between cells and nanoparticles is critical to advance the efficiency and safety of these drug delivery systems. To quantitatively track the motion of cell (transparent) and nanoparticles (nontransparent) with nanometer displacement sensitivity, we investigate a novel imaging technology, optically computed phase microscopy (OCPM) that processes 3D spatial-spectral data through optical computation. We demonstrate that OCPM has the capability to image the motion of cells and magnetic nanoparticles that are mechanically excited by an external magnetic field, quantitatively and in the en face plane.
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Registered trials
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