ArticleBiomedical optics express2022
Cytotoxicity analysis of oxazine 4-perchlorate fluorescence nerve potential clinical biomarker for guided surgery.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A Specimen-Separated Machine Learning Benchmark Toward Real-Time Tissue-Type Identification in Guided Surgery Using Ex Vivo Bovine Laser-Induced Breakdown Spectroscopy.Sensors (Basel, Switzerland) · 2026Article
- Digital Histopathological Discrimination of Label-Free Tumoral Tissues by Artificial Intelligence Phase-Imaging Microscopy.Sensors (Basel, Switzerland) · 2022Article
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Authors and funding
6 authors.
Funding
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Abstract
Biological tissue discrimination is relevant in guided surgery. Nerve identification is critical to avoid potentially severe collateral damage. Fluorescence imaging by oxazine 4-perchlorate (O4P) has been recently proposed. In this work, the cytotoxicity of O4P on U87 human-derived glioma cells has been investigated as a function of concentration and operating room irradiation modes. A custom-built optical irradiation device was employed for controlled optical dosimetry. DNA damage and O4P intracellular localization was also investigated by immunofluorescence and confocal microscopy. The results show that concentration below 100 µM can be considered safe. These results contribute to the assessment of the feasibility of O4P as a nerve biomarker.
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Registered trials
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