ArticleBiomedical optics express2022
Design of a radial multi-offset detection pattern for
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Characterization of Leukocyte Crawling in the Living Human Retina Using Adaptive Optics Scanning Light Ophthalmoscopy.Investigative ophthalmology & visual science · 2026Article
- Single wavelength, dual temporal offset module for AOSLO systems.Biomedical optics express · 2026Article
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- Distribution and dynamics of motile immune cells near the inner limiting membrane in the living human eye.Biomedical optics express · 2025Article
- Revealing neurovascular coupling at a high spatial and temporal resolution in the living human retina.Science advances · 2025Article
- Deep compressed multichannel adaptive optics scanning light ophthalmoscope.Science advances · 2025Article
- Review
- Are the Hypo-Reflective Clumps Associated With Age-Related Macular Degeneration in Adaptive Optics Ophthalmoscopy Autofluorescent?Investigative ophthalmology & visual science · 2024Article
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- High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope.Biomedical optics express · 2024Article
- Editorial: Advances in optical imaging for ophthalmology: new developments, clinical applications and perspectives.Frontiers in ophthalmology · 2024Article
- Minimum intensity projection of embossed quadrant-detection images for improved photoreceptor mosaic visualisation.Frontiers in ophthalmology · 2024Article
- Retinal Arteriolar Wall Remodeling in Diabetes Captured With AOSLO.Translational vision science & technology · 2023Article
- Twenty-five years of clinical applications using adaptive optics ophthalmoscopy [Invited].Biomedical optics express · 2023Review
- Insights into Sickle Cell Disease through the Retinal Microvasculature: Adaptive Optics Scanning Light Ophthalmoscopy Correlates of Clinical OCT Angiography.Ophthalmology science · 2022Article
- Imaging of vitreous cortex hyalocyte dynamics using non-confocal quadrant-detection adaptive optics scanning light ophthalmoscopy in human subjects.Biomedical optics express · 2022Article
- Label-Free Imaging of Inflammation at the Level of Single Cells in the Living Human Eye.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Previous work has shown that multi-offset detection in adaptive optics scanning laser ophthalmoscopy (AOSLO) can be used to image transparent cells such as retinal ganglion cells (RGCs) in monkeys and humans. Though imaging in anesthetized monkeys with high light levels produced high contrast images of RGCs, images from humans failed to reach the same contrast due to several drawbacks in the previous dual-wavelength multi-offset approach. Our aim here was to design and build a multi-offset detection pattern for humans at safe light levels that could reveal transparent cells in the retinal ganglion cell layer with a contrast and acquisition time approaching results only previously obtained in monkeys. Here, we present a new single-wavelength solution that allows for increased light power and eliminates problematic chromatic aberrations. Then, we demonstrate that a radial multi-offset detection pattern with an offset distance of 8-10 Airy Disk Diameter (ADD) is optimal to detect photons multiply scattered in all directions from weakly reflective retinal cells thereby enhancing their contrast. This new setup and image processing pipeline led to improved imaging of inner retinal cells, including the first images of microglia with multi-offset imaging in AOSLO.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.