Evidence map›Paper›PMID 35154830›Full record

ArticleProstate cancer2022

MRI-Based Radiotherapy Planning to Reduce Rectal Dose in Excess of Tolerance.

Daniel R Schmidt, Mandar Bhagwat, Daniel I Glazer, Ming-Hui Chen, Maryam Moteabbed, Elizabeth McMahon, Marian J Loffredo, Clare M Tempany, Anthony V D'Amico

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostate cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02470910 (Incorporating MR Imaging Into Prostate Radiotherapy Treatment Planning), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02470910 nacompletednot on this map

Incorporating MR Imaging Into Prostate Radiotherapy Treatment Planning: A Pilot Study to Quantitate the Potential to Limit Radiation Dose to Normal Tissues.

TypeinterventionalSponsorDana-Farber Cancer InstituteRan2015 to 2018Enrolled15ConditionsProstate Cancer, Adenocarcinoma of the Prostate Stage I, Adenocarcinoma of the Prostate Stage II, Adenocarcinoma of the Prostate Stage IIIArmsMagnetic Resonance Imaging
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Daniel R SchmidtDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.ORCID https://orcid.org/0000-0001-6192-0378
Mandar BhagwatHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Daniel I GlazerHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0002-1547-5215
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Philip E. Austin Bldg, 3rd floor, Storrs, CT 06269, USA.
Maryam MoteabbedHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Elizabeth McMahonHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Marian J LoffredoDepartment of Radiation Oncology, 75 Francis St, Brigham and Women's Hospital, Boston, MA 02115, USA.
Clare M TempanyHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Anthony V D'AmicoHarvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0002-4084-9944
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USHarvard University · USUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MATERIALS AND

methodsThis prospective single-arm study enrolled 15 men treated with IG-IMRT for localized prostate cancer. All participants received a dedicated 3 Tesla MRI examination of the prostate in addition to a pelvic CT examination for treatment planning. Two volumetric modulated arc therapy (VMAT) plans with a prescription dose of 79.2 Gy were designed using identical constraints based on CT- and MRI-defined consensus volumes. The volume of rectum exposed to 70 Gy or more was compared using the Wilcoxon paired signed rank test.

resultsFor CT-based treatment plans, the median volume of rectum receiving 70 Gy or more was 9.3 cubic centimeters (cc) (IQR 7.0 to 10.2) compared with 4.9 cc (IQR 4.1 to 7.8) for MRI-based plans. This resulted in a median volume reduction of 2.1 cc (IQR 0.5 to 5.3,

conclusionsUsing MRI to plan prostate IG-IMRT to a dose of 79.2 Gy reduces the volume of rectum receiving radiation dose in excess of tolerance (70 Gy or more) and should be considered in men who are at high risk for late rectal toxicity and are not good candidates for other rectal sparing techniques such as hydrogel spacer. This trial is registered with NCT02470910.

Identifiers

PMID35154830
PMCPMC8831048
OpenAlexW4210682751

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.