Evidence map›Paper›PMID 35154816›Full record

ArticleCrystals2021

Engineering Crystal Packing in RNA-Protein Complexes II: A Historical Perspective from the Structural Studies of the Spliceosome.

Adelaine Kwun-Wai Leung, Yasushi Kondo, Daniel A Pomeranz Krummel, Jade Li, Stephen R Price, Anne-Marie M van Roon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Crystals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Structural studies of the spliceosome: Bridging the gaps.Current opinion in structural biology · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Adelaine Kwun-Wai LeungDepartment of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada.ORCID https://orcid.org/0000-0002-2849-4474
Yasushi KondoDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.ORCID https://orcid.org/0000-0003-2131-575X
Daniel A Pomeranz KrummelDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Jade LiStructural Studies Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Stephen R PriceResearch Department of Cell and Developmental Biology, UCL Division of Biosciences, London WC1E 6DE, UK.
Anne-Marie M van RoonStructural Studies Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
MRC Laboratory of Molecular Biology · GBQB3 · USUniversity College London · GBUniversity of Cincinnati Medical Center · USUniversity of Saskatchewan · CA

Funding

Medical Research Council MC_U105197215Medical Research Council MC_UP_1201/19
6 · The paper itself

Abstract

Cryo-electron microscopy has greatly advanced our understanding of how the spliceosome cycles through different conformational states to conduct the chemical reactions that remove introns from pre-mRNA transcripts. The Cryo-EM structures were built upon decades of crystallographic studies of various spliceosomal RNA-protein complexes. In this review we give an overview of the crystal structures solved in the Nagai group, utilizing many of the strategies to design crystal packing as described in the accompanying paper.

Indexed as

crystallizationRNA-protein complexesspliceosome

Identifiers

PMID35154816
PMCPMC7612351
OpenAlexW3193631421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.