Evidence map›Paper›PMID 35154723›Full record

ArticleClinical case reports2022

Avoidance of surgery for head and neck infantile myofibromatosis using imatinib monotherapy.

Prasanth Pattisapu, Tara L Wenger, John P Dahl, Randall A Bly, Juliana Bonilla-Velez, Natalie Wu, Anurekha Hall, Erin R Rudzinski, Jonathan A Perkins

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Molecular Characterization of a ComplexJCO precision oncology · 2026
    Article
  2. Article
  3. Article
  4. High-Grade Sarcomas with Myogenic Differentiation Harboring Hotspot PDGFRB Mutations.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Prasanth PattisapuDepartment of Otolaryngology-Head & Neck Surgery Nationwide Children's Hospital and The Ohio State University Columbus Ohio USA.ORCID https://orcid.org/0000-0002-6857-2086
Tara L WengerDepartment of Genetic Medicine University of Washington School of Medicine Seattle Washington USA.
John P DahlDepartment of Otolaryngology-Head & Neck Surgery University of Washington School of Medicine Seattle Washington USA.ORCID https://orcid.org/0000-0003-2728-3576
Randall A BlyDepartment of Otolaryngology-Head & Neck Surgery University of Washington School of Medicine Seattle Washington USA.ORCID https://orcid.org/0000-0001-5308-527X
Juliana Bonilla-VelezDepartment of Otolaryngology-Head & Neck Surgery University of Washington School of Medicine Seattle Washington USA.ORCID https://orcid.org/0000-0002-7174-7609
Natalie WuDepartment of Pediatrics Division of Hematology/Oncology University of Washington School of Medicine Seattle Washington USA.
Anurekha HallDepartment of Pediatrics Division of Hematology/Oncology University of Washington School of Medicine Seattle Washington USA.
Erin R RudzinskiDivision of Pathology Seattle Children's Hospital Seattle Washington USA.
Jonathan A PerkinsDepartment of Otolaryngology-Head & Neck Surgery University of Washington School of Medicine Seattle Washington USA.ORCID https://orcid.org/0000-0003-0181-3997
Seattle Children's Hospital · USNationwide Children's Hospital · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Describe a novel use for a kinase inhibitor, imatinib, in young children with a known activated somatic mutation in PDGFR-beta. Two patients with infantile myofibromatosis treated with imatinib. Case description of evaluation, diagnosis and treatment decisions for infantile myfibromatosis of the head and neck. Description of medical therapy for infantile myofibromatosis in these patients. For function threatening myofibromas of a known genotype, in infants, targeted medical therapy is a treatment option.

Indexed as

imatinibInfantile myofibromatosisPDGFRBprecision medicine

Identifiers

PMID35154723
PMCPMC8826127
OpenAlexW4210826492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.