Evidence map›Paper›PMID 35154526›Full record

ArticleArchives of medical science : AMS2022

The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients.

Maha M Allam, Karema A Diab, Fatma O Khalil, Fatma A Khalaf, Mohamed Abdel-Samiee, Nashwa Sheble, Mohamed A Eljaky, Essam Zayed, Warda Othman, Mervat Abd-Elkreem and 1 more

Open access · goldAbstract read
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In one paragraph

Article in Archives of medical science : AMS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Maha M AllamClinical Pathology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Karema A DiabClinical Pathology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Fatma O KhalilMicrobiology and Immunology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Fatma A KhalafBiochemistry Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Mohamed Abdel-SamieeHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Nashwa ShebleHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Mohamed A EljakyHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Essam ZayedHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Warda OthmanHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Mervat Abd-ElkreemHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Eman AbdelsameeaHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Liver Institute Northwest · USMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe development and progression of hepatocellular carcinoma (HCC) is a multistage process involving the deregulation of genes that are crucial to cellular processes. Multiple risk factors are correlated with HCC. MicroRNA is differentially expressed in the development of different types of malignancies, including hepatic malignancy. Single nucleotide polymorphisms (SNPs) are the most common sequence variation in the human genome. SNPs in miRNAs may affect transcription, processing, or target recognition and result in malignant disease. The aim of the study was to determine the association between microRNA gene polymorphisms and the development of HCC in Egyptian patients. MATERIAL AND

methodsThis study included 200 individuals who were matched in age and sex. Tumour staging was done using the BCLC staging system. Quantification and genotyping of microRNA were performed.

resultsAmong the 200 patients, 2 groups were described: group I included 90 HCC patients with a male majority (72.2%), and group II comprised 110 controls. Three microRNA SNPs were assayed in both patients and controls. There was a significant association between rs10061133 miR-499b and the risk of HCC. The genotypes GG or G allele were significantly associated with an increased risk of HCC (GG: OR = 2.91, 95% CI: 1.23-4.22,

conclusionsThere is an association between the miRNA SNPs and the susceptibility to HCC, to explore some roles and mechanisms of SNPs within miRNAs in the occurrence and development of HCC.

Indexed as

gene polymorphismshepatocellular carcinomamicroRNA

Identifiers

PMID35154526
PMCPMC8826692
OpenAlexW3149555600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.