Evidence map›Paper›PMID 35154260›Full record

ArticleFrontiers in genetics2021

Identification of Alternative Polyadenylation in

Leonard Schärfen, Dagmar Zigackova, Kirsten A Reimer, Martha R Stark, Viktor A Slat, Nancy J Francoeur, Melissa L Wells, Lecong Zhou, Perry J Blackshear, Karla M Neugebauer and 1 more

Abstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leonard SchärfenDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, United States.
Dagmar ZigackovaDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, United States.
Kirsten A ReimerDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, United States.
Martha R StarkDepartment of Chemistry, University of Northern British Columbia, Prince George, BC, Canada.
Viktor A SlatDepartment of Chemistry, University of Northern British Columbia, Prince George, BC, Canada.
Nancy J FrancoeurDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Melissa L WellsThe Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, United States.
Lecong ZhouIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, United States.
Perry J BlackshearThe Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, United States.
Karla M NeugebauerDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, United States.
Stephen D RaderDepartment of Chemistry, University of Northern British Columbia, Prince George, BC, Canada.

Funding

Cross-regulation between transcription and pre-mRNA splicingR01GM112766 · NIGMS · YALE UNIVERSITY · PI Karla M Neugebauer · 2015 to 2026
$5.3M
Biogenesis and function of a novel class of stress-induced long non-coding RNAsR01GM140735 · NIGMS · YALE UNIVERSITY · PI NEUGEBAUER, KARLA M, STEITZ, JOAN A. · 2021 to 2024
$1.7M
Analysis of transcription and splicing coordination during erythropoeisis using single molecule RNA-seqR21HL150642 · NHLBI · YALE UNIVERSITY · PI NEUGEBAUER, KARLA M, PILLAI, MANOJ M. · 2020 to 2021
$459k
NHLBI NIH HHS R21 HL150642NIGMS NIH HHS R01 GM112766NIGMS NIH HHS R01 GM140735
6 · The paper itself

Abstract

Alternative polyadenylation (APA) is widespread among metazoans and has been shown to have important impacts on mRNA stability and protein expression. Beyond a handful of well-studied organisms, however, its existence and consequences have not been well investigated. We therefore turned to the deep-branching red alga,

Indexed as

alternative polyadenylationcleavage and polyadenylationCyanidioschyzon merolaeintron retentionnitrogen stresspolyadenylation (polyA) signalpolyadenylation site (PAS)splicing

Identifiers

PMID35154260
PMCPMC8831791

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.