Evidence map›Paper›PMID 35154249›Full record

ArticleFrontiers in genetics2021

Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered.

Angela Taraschi, Costanza Cimini, Alessia Colosimo, Marina Ramal-Sanchez, Fadl Moussa, Samia Mokh, Luca Valbonetti, Giulia Capacchietti, Israiel Tagaram, Nicola Bernabò and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Angela TaraschiFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Costanza CiminiFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Alessia ColosimoFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Marina Ramal-SanchezFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Fadl MoussaFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Samia MokhNational Council for Scientific Research (CNRS), Lebanese Atomic Energy Commission (LAEC), Laboratory for Analysis of Organic Compound (LACO), Beiru, Lebanon.
Luca ValbonettiFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Giulia CapacchiettiFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Israiel TagaramFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Nicola BernabòFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Barbara BarboniFaculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
University of Teramo · ITInstitute of Cell Biology and Neurobiology · ITIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale · ITLebanese University · LBNational Council for Scientific Research · LBNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human hypofertility and infertility are two worldwide conditions experiencing nowadays an alarming increase due to a complex ensemble of events. The immune system has been suggested as one of the responsible for some of the etiopathogenic mechanisms involved in these conditions. To shed some light into the strong correlation between the reproductive and immune system, as can be inferred by the several and valuable manuscripts published to date, here we built a network using a useful bioinformatic tool (DisGeNET), in which the key genes involved in the sperm-oviduct interaction were linked. This constitutes an important event related with Human fertility since this interaction, and specially the spermatozoa, represents a not-self entity immunotolerated by the female. As a result, we discovered that some proteins involved in the sperm-oviduct interaction are implicated in several immune system diseases while, at the same time, some immune system diseases could interfere by using different pathways with the reproduction process. The data presented here could be of great importance to understand the involvement of the immune system in fertility reduction in Humans, setting the basis for potential immune therapeutic tools in the near future.

Indexed as

asthmabiological networkdiseasomehumanimmune systemimmunological diseaseoviductal environmentrheumatoid arthritis

Identifiers

PMID35154249
PMCPMC8829125
OpenAlexW4210547666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.