Evidence map›Paper›PMID 35154147›Full record

ReviewFrontiers in immunology2022

Train the Trainer: Hematopoietic Stem Cell Control of Trained Immunity.

Marco De Zuani, Jan Frič

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Dysregulated Bone Marrow Contributes to Glomerular Injury through Soluble Factors.Journal of the American Society of Nephrology : JASN · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Trained immunity in farm animals.Veterinary research · 2025
    Review
  12. Article
  13. Article
  14. C1q reprograms innate immune memory.Frontiers in immunology · 2025
    Article
  15. Trained immunity suppression determines kidney allograft survival.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marco De ZuaniInternational Clinical Research Center, St. Anne's University Hospital, Brno, Czechia.
Jan FričInternational Clinical Research Center, St. Anne's University Hospital, Brno, Czechia.
University Hospital Brno · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence shows that innate immune cells, in addition to B and T cells, can retain immunological memory of their encounters and afford long-term resistance against infections in a process known as 'trained immunity'. However, the duration of the unspecific protection observed

Indexed as

CytokinesHematopoietic Stem CellsHumansImmunity, InnateImmunologic MemoryLigandsToll-Like ReceptorsCytokinesLigandsToll-Like Receptorshematopoietic stem cellsHSPCsinnate immunitymyeloid cellsprogenitor cellstrained immunity

Identifiers

PMID35154147
PMCPMC8828730
OpenAlexW4210283562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.