Evidence map›Paper›PMID 35154088›Full record

ReviewFrontiers in immunology2021

Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria.

Melissa A Colden, Sushant Kumar, Bolormaa Munkhbileg, Daria V Babushok

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Molecular diagnostics 101: how to use genetic tests in classical hematology.Hematology. American Society of Hematology. Education Program · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Promise of gene therapy for congenital neurologic disease due to GPI deficiency.Molecular therapy. Methods & clinical development · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Melissa A ColdenDivision of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Sushant KumarDivision of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Bolormaa MunkhbilegDivision of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Daria V BabushokDivision of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Early Clonal Evolution in Acquired Aplastic AnemiaK08HL132101 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BABUSHOK, DARIA · 2016 to 2021
$992k
NCATS NIH HHS UL1 TR001878NHLBI NIH HHS K08 HL132101
6 · The paper itself

Abstract

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a disease as simple as it is complex. PNH patients develop somatic loss-of-function mutations in phosphatidylinositol

Indexed as

AnimalsAutoimmunityBiomarkersClonal EvolutionCytokinesDisease ManagementDisease Models, AnimalDisease SusceptibilityGenetic Predisposition to DiseaseGlycosylphosphatidylinositolsHematopoiesisHemoglobinuria, ParoxysmalHumansLymphocyte SubsetsMutationBiomarkersCytokinesGlycosylphosphatidylinositolsaplastic anemia (AA)autoimmunitybone marrow failure (BMF)clonal hematopoeisiscomplementGPI-anchoredparoxysmal nocturnal hemoglobinuriaPIGA

Identifiers

PMID35154088
PMCPMC8831232
OpenAlexW4210388678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.