SynthesisFrontiers in psychology2021
Pure Tone Audiometry and Hearing Loss in Alzheimer's Disease: A Meta-Analysis.
Synthesis in Frontiers in psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- A meta-analytic approach to identification of clinical biomarkers of hearing loss in cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Association of age-related hearing loss with cognitive impairment and dementia: an umbrella review.Frontiers in aging neuroscience · 2023Pooled it
- The incidence of sensorineural hearing loss diagnoses in people with and without Alzheimer's disease - a nationwide cohort study.BMC geriatrics · 2025Article
- Vestibular Hypofunction in Patients with Presbycusis: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Cognitive Screening and Hearing Assessment in Patients With Chronic Tinnitus.Clinical and experimental otorhinolaryngology · 2024Article
- Polygenic Risk Score-Based Association Analysis of Speech-in-Noise and Hearing Threshold Measures in Healthy Young Adults with Self-reported Normal Hearing.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Functional topography of the neocortex predicts covariation in complex cognitive and basic motor abilities.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Functional Topography of the Neocortex Predicts Covariation in Complex Cognitive and Basic Motor Abilities.bioRxiv : the preprint server for biology · 2023Article
- Editorial: Hearing Loss and Cognitive Disorders.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) has been widely reported. However, the nature of this relationship remains poorly understood. Quantification of hearing loss as it relates to AD is imperative for the creation of reliable, hearing-related biomarkers for earlier diagnosis and development of ARHL treatments that may slow the progression of AD. Previous studies that have measured the association between peripheral hearing function and AD have yielded mixed results. Most of these studies have been small and underpowered to reveal an association. Therefore, in the current report, we sought to estimate the degree to which AD patients have impaired hearing by performing a meta-analysis to increase statistical power. We reviewed 248 published studies that quantified peripheral hearing function using pure-tone audiometry for subjects with AD. Six studies, with a combined total of 171 subjects with AD compared to 222 age-matched controls, met inclusion criteria. We found a statistically significant increase in hearing threshold as measured by pure tone audiometry for subjects with AD compared to controls. For a three-frequency pure tone average calculated for air conduction thresholds at 500-1,000-2,000 Hz (0.5-2 kHz PTA), an increase of 2.3 decibel hearing level (dB HL) was found in subjects with AD compared to controls (
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