ArticleFrontiers in physiology2021
Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- The Statin Floor Effect: a Mechanistic Framework for Residual Cardiovascular Risk.Cardiovascular drugs and therapy · 2026Review
- Digital twins and digital models of the human circulatory system.Nature reviews bioengineering · 2026Article
- Multidimensional optimization of stent design for endothelial shear stress regulation: Geometric structuring, surface functionalization strategies to mitigate thrombosis and restenosis.International journal of cardiology. Heart & vasculature · 2025Review
- Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Hemodynamic changes for half cover left subclavian artery ostium during thoracic endovascular aortic repair.Frontiers in surgery · 2024Article
- Vascularized organ bioprinting: From strategy to paradigm.Cell proliferation · 2023Review
- Effect of balloon pre-dilation on performance of self-expandable nitinol stent in femoropopliteal artery.Biomechanics and modeling in mechanobiology · 2023Article
- Cardiovascular deconditioning and impact of artificial gravity during 60-day head-down bed rest-Insights from 4D flow cardiac MRI.Frontiers in physiology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHemodynamics-induced low wall shear stress (WSS) is one of the critical reasons leading to vascular remodeling. However, the coupling effects of WSS and cellular kinetics have not been clearly modeled. The aim of this study was to establish a multiscale modeling approach to reveal the vascular remodeling behavior under the interaction between the macroscale of WSS loading and the microscale of cell evolution.
methodsComputational fluid dynamics (CFD) method and agent-based model (ABM), which have significantly different characteristics in temporal and spatial scales, were adopted to establish the multiscale model. The CFD method is for the second/organ scale, and the ABM is for the month/cell scale. The CFD method was used to simulate blood flow in a vessel and obtain the WSS in a vessel cross-section. The simulations of the smooth muscle cell (SMC) proliferation/apoptosis and extracellular matrix (ECM) generation/degradation in a vessel cross-section were performed by using ABM. During the simulation of the vascular remodeling procedure, the damage index of the SMC and ECM was defined as deviation from the obtained WSS. The damage index decreased gradually to mimic the recovery of WSS-induced vessel damage.
results(1) The significant wall thickening region was consistent with the low WSS region. (2) There was no evident change of wall thickness in the normal WSS region. (3) When the damage index approached to 0, the amount and distribution of SMCs and ECM achieved a stable state, and the vessel reached vascular homeostasis.
conclusionThe established multiscale model can be used to simulate the vascular remodeling behavior over time under various WSS conditions.
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