ArticleNational journal of maxillofacial surgery
Evaluation of matrix metalloproteinase 9 gene expression in oral squamous cell carcinoma and its clinicopathological correlation.
Article in National journal of maxillofacial surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 2 citations in OpenAlex.
- Repurposing antifungal drugs for Oral squamous cell carcinoma using network pharmacology, molecular docking and molecular dynamics approaches.Journal, genetic engineering & biotechnology · 2026Article
- Diagnostic utility of salivary LDH and MMP-9 in differentiating oral cancer from potentially malignant disorders.Bioinformation · 2026Article
- Article
- Evaluation of salivary matrix metalloproteinase-12 levels in patients with oral lekoplakia and oral squamous cell carcinoma using enzyme-linked immunosorbent assay.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMatrix metalloproteinases (MMPs) are calcium-dependent and zinc-containing endopeptidases which enhance cancer progression by regulating angiogenesis, migration, proliferation, and invasion. Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in India, and it is observed over 90% of cases. In OSCC, MMP9 which belongs to the gelatinase group promotes tumor progression by angiogenesis, disturbing tissue morphology that allows tumor growth which breaks the basement membrane and enables metastasis, and its overexpression in OSCC is proven to have prognostic value. AIM AND
objectivesTo assess the expression of MMP9 in OSCC and to correlate the MMP9 expression with pathological staging of the OSCC. MATERIALS AND
methodsTen OSCC tissue samples and normal tissue samples were collected. Total RNA was extracted and the complementary DNA was generated. The specific primers used in the primers were synthesized. Total reaction volume was 20 μl. The polymerase chain reaction condition included 95°C for 30 s followed by 40 cycles of two steps: 95°C for 5 s and 60°C for 30 s. The relative quantification of genes was evaluated.
resultsUpregulation of MMP9 gene regulation was observed in OSCC tissue samples when compared to the controls. Correlating with the pathological staging, we observed that 30% tumors were stage IVA with involvement of adjacent structures and 30% had lymph node involvement.
conclusionThis study is done to assess the possibility of MMP9 gene expression as a prognostic biomarker for OSCC.
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