Evidence map›Paper›PMID 35153339›Full record

ArticleTetrahedron letters2021

Mercapto-functionalized polyhedral oligomeric silsesquioxane as a soluble support for the synthesis of peptide thioesters.

Kimberly Perry, Binglin Sui, Yangmei Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kimberly PerryDepartment of Drug Discovery & Biomedical Sciences, University of South Carolina, 715 Sumter St, Columbia, SC 29208, USA.
Binglin SuiDepartment of Drug Discovery & Biomedical Sciences, University of South Carolina, 715 Sumter St, Columbia, SC 29208, USA.
Yangmei LiDepartment of Drug Discovery & Biomedical Sciences, University of South Carolina, 715 Sumter St, Columbia, SC 29208, USA.
University of South Carolina Sumter · US

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KIARIS, HIPPOKRATIS, RONINSON, IGOR B · 2014 to 2024
$25.2M
TFEB Activator for Alzheimer’s Disease TherapyR41AG058364 · NIA · BRILLIANT BIOSCIENCES, INC. · PI LI, YANGMEI · 2018 to 2018
$225k
NIA NIH HHS R41 AG058364NIGMS NIH HHS P20 GM109091
6 · The paper itself

Abstract

The revival of peptide-based drugs has led to the increasing demand for the development of large-scale synthesis of these complex molecules. To meet this demand, the use of mercapto-functionalized polyhedral oligomeric silsesquioxane (POSS-SH) as a soluble support for the synthesis of a model pentapeptide POSS-thioester is reported. The synthetic process provided a total yield of 62% for the pentapeptide POSS-thioester and the 1H NMR spectra validated the high purity of the products. The successful synthesis of the pentapeptide POSS-thioester with high yield and purity provides a promising way to the scale-up chemical synthesis of peptide thioesters, peptides, peptide amides, cyclic peptides, and even proteins.

Indexed as

Peptide-based therapeuticsPolyhedral oligomeric silsesquioxaneScale-up synthesisSoluble supportThioester

Identifiers

PMID35153339
PMCPMC8833314
OpenAlexW3206460446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.