Evidence map›Paper›PMID 35152909›Full record

ArticleTrials2022

ICONIC study-conservative versus conventional oxygenation targets in intensive care patients: study protocol for a randomized clinical trial.

C C A Grim, L I van der Wal, H J F Helmerhorst, D J van Westerloo, P Pelosi, M J Schultz, E de Jonge, ICONIC Investigators and PROVE Network

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

C C A Grim *Department of Intensive Care, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.
L I van der Wal *Department of Intensive Care, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands. L.I.van_der_wal@lumc.nl.
H J F HelmerhorstDepartment of Intensive Care, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.
D J van WesterlooDepartment of Intensive Care, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.
P PelosiDepartment of Surgical Sciences and Integrated Diagnostics, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Largo R. Benzi 10, 16132, Genoa, Italy.
M J SchultzDepartment of Intensive Care, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
E de JongeDepartment of Intensive Care, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.
ICONIC Investigators and PROVE Network
University of Oxford · GBLeiden University Medical Center · NLOspedale Policlinico San Martino · ITAmsterdam University Medical Centers · NLMahidol University · TH

Funding

nederlandse organisatie voor wetenschappelijk onderzoek 401.16.009
6 · The paper itself

Abstract

backgroundOxygen therapy is a widely used intervention in acutely ill patients in the intensive care unit (ICU). It is established that not only hypoxia, but also prolonged hyperoxia is associated with poor patient-centered outcomes. Nevertheless, a fundamental knowledge gap remains regarding optimal oxygenation for critically ill patients. In this randomized clinical trial, we aim to compare ventilation that uses conservative oxygenation targets with ventilation that uses conventional oxygen targets with respect to mortality in ICU patients.

methodsThe "ConservatIve versus CONventional oxygenation targets in Intensive Care patients" trial (ICONIC) is an investigator-initiated, international, multicenter, randomized clinical two-arm trial in ventilated adult ICU patients. The ICONIC trial will run in multiple ICUs in The Netherlands and Italy to enroll 1512 ventilated patients. ICU patients with an expected mechanical ventilation time of more than 24 h are randomized to a ventilation strategy that uses conservative (PaO DISCUSSION: The ICONIC trial is expected to provide evidence on the effects of conservative versus conventional oxygenation targets in the ICU population. This study may guide targeted oxygen therapy in the future.

trial registrationTrialregister.nl NTR7376 . Registered on 20 July, 2018.

Indexed as

Critical CareQuality of LifeAdultHumansIntensive Care UnitsMulticenter Studies as TopicOxygen Inhalation TherapyRandomized Controlled Trials as TopicRespiration, ArtificialClinical trialIntensive careMechanical ventilationOxygenOxygen inhalation therapy

Identifiers

PMID35152909
PMCPMC8842972
OpenAlexW4213320420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.