Evidence map›Paper›PMID 35152881›Full record

ArticleJournal of neuroengineering and rehabilitation2022

Assessing inertial measurement unit locations for freezing of gait detection and patient preference.

Johanna O'Day, Marissa Lee, Kirsten Seagers, Shannon Hoffman, Ava Jih-Schiff, Łukasz Kidziński, Scott Delp, Helen Bronte-Stewart

Abstract read
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Closing the loop in DBS: A data-driven approach.Parkinsonism & related disorders · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Johanna O'Day *Department of Bioengineering, Stanford University, Stanford, CA, USA. odayj@stanford.edu.ORCID 0000-0001-7890-5019
Marissa Lee *Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Kirsten Seagers *Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Shannon HoffmanDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Ava Jih-SchiffDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Łukasz KidzińskiDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Scott Delp *Department of Bioengineering, Stanford University, Stanford, CA, USA.
Helen Bronte-Stewart *Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
TR&D Project 3: OpenSim for PredictionP41EB027060 · NIBIB · STANFORD UNIVERSITY · PI Joy P Ku · 2020 to 2026
$9.7M
Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic FeedbackUH3NS107709 · NINDS · STANFORD UNIVERSITY · PI BRONTE-STEWART, HELEN · 2019 to 2023
$6.1M
Technology DevelopmentP2CHD101913 · NICHD · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2020 to 2024
$4.1M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NIBIB NIH HHS P41 EB027060NICHD NIH HHS P2C HD101913NINDS NIH HHS UH3 NS107709
6 · The paper itself

Abstract

backgroundFreezing of gait, a common symptom of Parkinson's disease, presents as sporadic episodes in which an individual's feet suddenly feel stuck to the ground. Inertial measurement units (IMUs) promise to enable at-home monitoring and personalization of therapy, but there is a lack of consensus on the number and location of IMUs for detecting freezing of gait. The purpose of this study was to assess IMU sets in the context of both freezing of gait detection performance and patient preference.

methodsSixteen people with Parkinson's disease were surveyed about sensor preferences. Raw IMU data from seven people with Parkinson's disease, wearing up to eleven sensors, were used to train convolutional neural networks to detect freezing of gait. Models trained with data from different sensor sets were assessed for technical performance; a best technical set and minimal IMU set were identified. Clinical utility was assessed by comparing model- and human-rater-determined percent time freezing and number of freezing events.

resultsThe best technical set consisted of three IMUs (lumbar and both ankles, AUROC = 0.83), all of which were rated highly wearable. The minimal IMU set consisted of a single ankle IMU (AUROC = 0.80). Correlations between these models and human raters were good to excellent for percent time freezing (ICC = 0.93, 0.89) and number of freezing events (ICC = 0.95, 0.86) for the best technical set and minimal IMU set, respectively.

conclusionsSeveral IMU sets consisting of three IMUs or fewer were highly rated for both technical performance and wearability, and more IMUs did not necessarily perform better in FOG detection. We openly share our data and software to further the development and adoption of a general, open-source model that uses raw signals and a standard sensor set for at-home monitoring of freezing of gait.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseGaitHumansNeural Networks, ComputerPatient PreferenceFreezing of gaitInertial measurement unitsMachine learning

Identifiers

PMID35152881
PMCPMC8842967

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.