ArticleMolecular ecology2022
Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.
Article in Molecular ecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 54 citations in OpenAlex.
- Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemicScience advances · 2026Article
- Efficient amplicon panels for evaluating hybridization and genetic structure in the Schistosoma haematobium species group.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Quantitative ethology of schistosome miracidia characterizes a conserved snail peptide that inhibits host recognition.PLoS pathogens · 2025Article
- Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector.Journal of helminthology · 2025Article
- Abundant genetic variation is retained in many laboratory schistosome populations.PLoS pathogens · 2025Article
- The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata.Parasites & vectors · 2025Article
- Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets.Nature communications · 2025Article
- Pooled, Long-read Sequencing for Structural Variant Characterization in Schistosome Populations.Genome biology and evolution · 2025Article
- Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector.bioRxiv : the preprint server for biology · 2025Article
- Acute Appendicitis Secondary to Intestinal Schistosomiasis.Case reports in surgery · 2025Article
- Antimicrobial resistance and clonal relationships of Salmonella enterica Serovar Gallinarum biovar pullorum strains isolated in China based on whole genome sequencing.BMC microbiology · 2024Article
- Intra-specific variations in Schistosoma mansoni and their possible contribution to inconsistent virulence and diverse clinical outcomes.PLoS neglected tropical diseases · 2024Article
- Article
- Paleoparasitological analysis of a 15th-16th c. CE latrine from the merchant quarter of Bruges, Belgium: Evidence for local and exotic parasite infections.Parasitology · 2024Article
- Hybrid-Capture Target Enrichment in Human Pathogens: Identification, Evolution, Biosurveillance, and Genomic Epidemiology.Pathogens (Basel, Switzerland) · 2024Review
- Article
- The genome and transcriptome of the snailbioRxiv : the preprint server for biology · 2023Article
- Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas.Molecular biology and evolution · 2023Article
- It's a small world for parasites: evidence supporting the North American invasion of EuropeanProceedings. Biological sciences · 2023Article
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Authors and funding
18 authors at 9 institutions in 5 countries.
Funding
Abstract
Schistosoma mansoni, a snail-borne, blood fluke that infects humans, was introduced into the Americas from Africa during the Trans-Atlantic slave trade. As this parasite shows strong specificity to the snail intermediate host, we expected that adaptation to South American Biomphalaria spp. snails would result in population bottlenecks and strong signatures of selection. We scored 475,081 single nucleotide variants in 143 S. mansoni from the Americas (Brazil, Guadeloupe and Puerto Rico) and Africa (Cameroon, Niger, Senegal, Tanzania, and Uganda), and used these data to ask: (i) Was there a population bottleneck during colonization? (ii) Can we identify signatures of selection associated with colonization? (iii) What were the source populations for colonizing parasites? We found a 2.4- to 2.9-fold reduction in diversity and much slower decay in linkage disequilibrium (LD) in parasites from East to West Africa. However, we observed similar nuclear diversity and LD in West Africa and Brazil, suggesting no strong bottlenecks and limited barriers to colonization. We identified five genome regions showing selection in the Americas, compared with three in West Africa and none in East Africa, which we speculate may reflect adaptation during colonization. Finally, we infer that unsampled populations from central African regions between Benin and Angola, with contributions from Niger, are probably the major source(s) for Brazilian S. mansoni. The absence of a bottleneck suggests that this is a rare case of a serendipitous invasion, where S. mansoni parasites were pre-adapted to the Americas and able to establish with relative ease.
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