Evidence map›Paper›PMID 35152405›Full record

GuidelineClinical pharmacology and therapeutics2022

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.

Rhonda M Cooper-DeHoff, Mikko Niemi, Laura B Ramsey, Jasmine A Luzum, E Katriina Tarkiainen, Robert J Straka, Li Gong, Sony Tuteja, Russell A Wilke, Mia Wadelius and 11 more

Open access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Clinical pharmacology and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 12 pooled it
61.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 12 syntheses or guidelines pooled it, 312 citations in OpenAlex.

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  11. Genomewide Association Study of Simvastatin Pharmacokinetics.Clinical pharmacology and therapeutics · 2022
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128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 16 institutions in 4 countries.

Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Mikko NiemiDepartment of Clinical Pharmacology, Individualized Drug Therapy Research Program, University of Helsinki, Helsinki, Finland.
Laura B RamseyDivisions of Clinical Pharmacology & Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jasmine A LuzumDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
E Katriina TarkiainenDepartment of Clinical Pharmacology, Individualized Drug Therapy Research Program, University of Helsinki, Helsinki, Finland.
Robert J StrakaDepartment of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, Minnesota, USA.
Li GongDepartment of Biomedical Data Science, School of Medicine, Stanford University, Stanford, California, USA.
Sony TutejaDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Russell A WilkeDepartment of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota, USA.
Mia WadeliusDepartment of Medical Sciences, Clinical Pharmacogenomics & Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Eric A LarsonDepartment of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota, USA.
Dan M RodenDivision of Cardiovascular Medicine and Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Teri E KleinDepartment of Biomedical Data Science, School of Medicine, Stanford University, Stanford, California, USA.
Sook Wah YeeDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
Ronald M KraussDepartments of Pediatrics and Medicine, University of California, San Francisco, California, USA.
Richard M TurnerThe Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.
Latha PalaniappanDivision of Primary Care and Population Health, Stanford University School of Medicine, Stanford, California, USA.
Andrea GaedigkDivision of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Kathleen M GiacominiDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
Kelly E CaudleDivision of Pharmaceutical Sciences, Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Deepak VooraDepartment of Medicine, Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Stanford University · USUniversity of California, San Francisco · USUniversity of South Dakota · USAmerican Association of Colleges of Pharmacy · USDuke University · USHelsinki University Hospital · FISt. Jude Children's Research Hospital · USUniversity of Cincinnati Medical Center · USUniversity of Helsinki · FIUniversity of Liverpool · GBUniversity of Michigan–Ann Arbor · USUniversity of Minnesota · USUniversity of Missouri–Kansas City · USUniversity of Pennsylvania · USUppsala University · SEVanderbilt University Medical Center · US

Funding

PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2M
Sparking Advancements in Genomic MedicineU01HG007269 · NHGRI · UNIVERSITY OF FLORIDA · PI CAVALLARI, LARISA HUMMA, JOHNSON, JULIE A. · 2013 to 2024
$17.0M
Pharmacogenomics of Statin TherapyP50GM115318 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAUSS, RONALD M · 2015 to 2019
$14.0M
PharmGKB: pharmacogenomics discovery and implementationU24HG010615 · NHGRI · STANFORD UNIVERSITY · PI TERI Ellen KLEIN, Michelle Whirl-Carrillo · 2020 to 2026
$9.5M
Equipment Supplement for Discovery of Pharmacogenomic Biomarkers for OATP1B1 and OATP1B3R01GM117163 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLOREZ, JOSE CARLOS, HEDDERSON, MONIQUE MARIE · 2015 to 2023
$5.5M
Clinical Pharmacogenetics Implementation Consortium (CPIC)U24HG010135 · NHGRI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CAUDLE, KELLY E., KLEIN, TERI ELLEN · 2018 to 2022
$5.4M
Clinical Pharmacogenetics Implementation Consortium (CPIC)R24GM115264 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KLEIN, TERI ELLEN, RELLING, MARY V · 2015 to 2017
$3.6M
Precision Medicine for Heart Failure: The Role of Genomics in the Efficacy and Racial Disparity of Cornerstone PharmacotherapyK08HL146990 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUZUM, JASMINE A · 2019 to 2023
$772k
Impact of the gut microbiome on response to lipid lowering therapyK23HL143161 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI TUTEJA, SONY · 2019 to 2022
$695k
NHGRI NIH HHS U01 HG007269NHGRI NIH HHS U24 HG010135NHGRI NIH HHS U24 HG010615NHLBI NIH HHS K08 HL146990NHLBI NIH HHS K23 HL143161NIGMS NIH HHS P50 GM115318NIGMS NIH HHS R01 GM117163NIGMS NIH HHS R24 GM061374NIGMS NIH HHS R24 GM115264
6 · The paper itself

Abstract

Statins reduce cholesterol, prevent cardiovascular disease, and are among the most commonly prescribed medications in the world. Statin-associated musculoskeletal symptoms (SAMS) impact statin adherence and ultimately can impede the long-term effectiveness of statin therapy. There are several identified pharmacogenetic variants that impact statin disposition and adverse events during statin therapy. SLCO1B1 encodes a transporter (SLCO1B1; alternative names include OATP1B1 or OATP-C) that facilitates the hepatic uptake of all statins. ABCG2 encodes an efflux transporter (BCRP) that modulates the absorption and disposition of rosuvastatin. CYP2C9 encodes a phase I drug metabolizing enzyme responsible for the oxidation of some statins. Genetic variation in each of these genes alters systemic exposure to statins (i.e., simvastatin, rosuvastatin, pravastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin), which can increase the risk for SAMS. We summarize the literature supporting these associations and provide therapeutic recommendations for statins based on SLCO1B1, ABCG2, and CYP2C9 genotype with the goal of improving the overall safety, adherence, and effectiveness of statin therapy. This document replaces the 2012 and 2014 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for SLCO1B1 and simvastatin-induced myopathy.

Indexed as

Hydroxymethylglutaryl-CoA Reductase InhibitorsATP Binding Cassette Transporter, Subfamily G, Member 2Cytochrome P-450 CYP2C9GenotypeHumansLiver-Specific Organic Anion Transporter 1Neoplasm ProteinsPharmacogeneticsRosuvastatin CalciumSimvastatinABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2CYP2C9 protein, humanCytochrome P-450 CYP2C9Hydroxymethylglutaryl-CoA Reductase InhibitorsLiver-Specific Organic Anion Transporter 1Neoplasm ProteinsRosuvastatin CalciumSimvastatinSLCO1B1 protein, human

Identifiers

PMID35152405
PMCPMC9035072
OpenAlexW4213127162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.