Evidence map›Paper›PMID 35152364›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2022

Current status of precision medicine in pediatric oncology in Spain: a consensus report by the Spanish Society of Paediatric Haematology and Oncology (SEHOP).

P Gargallo, F Bautista, A Juan-Ribelles, E Izquierdo, A Soriano, T de Rojas, A Escudero, C Lavarino, P Solano, R Hladun and 13 more

Abstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

P GargalloResearch Institute Hospital La Fe, Valencia, Spain. pablogt28@gmail.com.ORCID http://orcid.org/0000-0001-9720-8542
F BautistaClinical Trials Unit, Pediatric Hematology-Oncology Division, Hospital Universitario Niño Jesús, Madrid, Spain.
A Juan-RibellesPediatric Oncology and Hematology Unit, La Fe University Hospital, Valencia, Spain.
E IzquierdoPediatric OncoGenomics Unit, Pediatric Hematology-Oncology Department, Children's University Hospital Niño Jesús, Madrid, Spain.
A SorianoGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
T de RojasPediatric OncoGenomics Unit, Pediatric Hematology-Oncology Department, Children's University Hospital Niño Jesús, Madrid, Spain.
A EscuderoTranslational Research in Pediatric Oncology, Hematopoietic Stem Cell Transplantation, Cell Therapy, INGEMM-IdiPAZ, La Paz University Hospital, Madrid, Spain.
C LavarinoLaboratory of Molecular Oncology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
P SolanoDepartment of Pediatric Oncology, Hospital Infantil Virgen del Rocio, Sevilla, Spain.
R HladunGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
A Rubio-San-SimónClinical Trials Unit, Pediatric Hematology-Oncology Division, Hospital Universitario Niño Jesús, Madrid, Spain.
I Martínez-RomeraPediatric Hematology and Oncology Unit, Madrid Montepríncipe Hospital, Madrid, Spain.
I CalabriaOncology Department, Health in Code Group, Paterna, Valencia, Spain.
N G OlacireguiLaboratory of Molecular Oncology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
A Castañeda-HerediaDepartment of Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
E de ÁlavaInstitute of Biomedicine of Seville, Virgen del Rocío University Hospital/CSIC/University of Sevilla/CIBERONC, Sevilla, Spain.
A Pérez-MartínezPediatric Hemato-Oncology Department, Hospital Universitario La Paz, Madrid, Spain.
I AstigarragaServicio de Pediatria, Bio Cruces Health Research Institute, Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain.
A Patiño-GarcíaLaboratory and Department of Pediatrics, University Clinic of Navarra and Solid Tumor Area, CIMA, IdiSNA, Pamplona, Spain.
J AlonsoInstituto de Investigación de Enfermedades Raras and U758 (CB06/07/1009), CIBERER, Instituto de Salud Carlos III, Unidad de Tumores Sólidos Infantiles, Madrid, Spain.
A Fernández-TeijeiroPediatric Oncology and Hematology Unit, Hospital Universitario Virgen Macarena, Seville University, Seville, Spain.
A CañetePediatric Oncology and Hematology Unit, La Fe University Hospital, Valencia, Spain.
L MorenoGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study analyzes the current status of personalized medicine in pediatric oncology in Spain. It gathers national data on the tumor molecular studies and genomic sequencing carried out at diagnosis and at relapse, the centers that perform these studies, the technology used and the interpretation and clinical applicability of the results. Current challenges and future directions to achieve a coordinated national personalized medicine strategy in pediatric oncology are also discussed. Next generation sequencing-based (NGS) gene panels are the technology used in the majority of centers and financial limitations are the main reason for not incorporating these studies into routine care. Nowadays, the application of precision medicine in pediatric oncology is a reality in a great number of Spanish centers. However, its implementation is uneven and lacks standardization of protocols; therefore, national coordination to overcome the inequalities is required. Collaborative work within the Personalized Medicine Group of SEHOP is an adequate framework for encouraging a step forward in the effort to move precision medicine into the national healthcare system.

Indexed as

HematologyNeoplasmsChildHigh-Throughput Nucleotide SequencingHumansPrecision MedicineSpainMolecular biomarkersNext generation sequencingOnco-genomicsPediatric oncologyPersonalized medicineTargeted therapies

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.