SynthesisSocial psychiatry and psychiatric epidemiology2022
Fear of relapse in schizophrenia: a mixed-methods systematic review.
Synthesis in Social psychiatry and psychiatric epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- The dynamic interplay between anxiety-related, psychotic, and suicidal experiences: a qualitative study.BMC psychiatry · 2025Trial
- The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders.The British journal of psychiatry : the journal of mental science · 2025Trial
- "It's like having a friend in your pocket." the service user experience of the Actissist digital health intervention for early psychosis: a qualitative study.BMC psychiatry · 2025Trial
- Using EMPOWER in daily life: a qualitative investigation of implementation experiences.BMC psychiatry · 2023Trial
- Clozapine levels in inpatients with schizophrenia are not a predictor of rehospitalization: a naturalistic retrospective study.Pharmacological reports : PR · 2026Article
- "I need to talk, to talk to people": a qualitative study of service user and carer views and priorities for social functioning in schizophrenia-spectrum disorders.Community mental health journal · 2026Article
- The ILIA study: protocol for a randomized-controlled multicenter clinical trial on smartphone- and web-based relapse monitoring for patients with schizophrenia or schizoaffective disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- A CNN-Transformer Fusion Model for Proactive Detection of Schizophrenia Relapse from EEG Signals.Bioengineering (Basel, Switzerland) · 2025Article
- Association of relapse with all-cause mortality in adult patients with stable schizophrenia.The international journal of neuropsychopharmacology · 2025Article
- Factors influencing fear of disease recurrence in postoperative craniopharyngioma patients.American journal of translational research · 2025Article
- Internet Fraud among Patients Admitted for Psychoactive Substance Use Disorders in Selected Hospitals of Southwestern Nigeria: Prevalence, Predictors, and Implications.Addiction & health · 2025Article
- Article
- Measurement of Adverse Events in Studies of Digital Health Interventions for Psychosis: Guidance and Recommendations Based on a Literature Search and Framework Analysis of Standard Operating Procedures.Schizophrenia bulletin · 2024Article
- Perception of risk of relapse among patients with first episode and recurrent schizophrenia: a descriptive phenomenological study.BMC psychiatry · 2023Article
- Learner experiences of a carer-focused massive open online course on psychosis: A qualitative study.Digital healthArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFears of relapse in people diagnosed with schizophrenia have long been recognised as an impediment to recovery and wellbeing. However, the extent of the empirical basis for the fear of relapse concept is unclear. A systematic review is required to collate available evidence and define future research directions.
methodsA pre-registered systematic search (PROSPERO CRD42020196964) of four databases (PubMED, MEDLINE-Ovid, PsycINFO-Ovid, and Cochrane Central Register of Controlled Trials) was conducted from their inception to 05/04/2021.
resultsWe found nine eligible studies. Five were quantitative (4 descriptive and 1 randomised controlled trial), and four were qualitative. The available quantitative evidence suggests that fear of relapse may have concurrent positive relationships with depression (r = 0.72) and suicide ideation (r = 0.48), and negative relationship with self-esteem (r = 0.67). Qualitative synthesis suggests that fear of relapse is a complex phenomenon with behavioural and emotional components which has both direct and indirect effects on wellbeing.
conclusionsEvidence in this area is limited and research with explicit service user and carer involvement is urgently needed to develop new and/or refine existing measurement tools, and to measure wellbeing rather than psychopathology. Nonetheless, clinicians should be aware that fear of relapse exists and appears to be positively associated with depression and suicide ideation, and negatively associated with self-esteem. Fear of relapse can include fears of losing personal autonomy and/or social/occupational functioning. It appears to impact carers as well as those diagnosed with schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.