ArticleJournal of radiation research2022
Three cases of retroperitoneal sarcoma in which bioabsorbable spacers (bioabsorbable polyglycolic acid spacers) were inserted prior to carbon ion radiotherapy.
Article in Journal of radiation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Endoscopic Spacer-Assisted Stereotactic Body Radiation Therapy for Abdominal Oligometastases: A Novel Technique to Reduce Gastrointestinal Toxicity.Advances in radiation oncology · 2026Article
- A novel technique of spacer implantation and proton beam therapy for hilar cholangiocarcinoma: a case report.Frontiers in oncology · 2026Article
- Technical report on the first clinical use of a bioabsorbable PGA spacer in HDR brachytherapy for recurrent cervical cancer.Journal of radiation research · 2025Article
- Dose-Volume Constraints for Thoracic, Abdominal, and Pelvic Carbon Ion Radiotherapy: A Literature Review.Cancer medicine · 2025Review
- Hydronephrosis Caused by Polyglycolic Acid Spacer Placement Prior to Carbon Ion Radiotherapy for Local Recurrence of Rectal Cancer: Case Report.Surgical case reports · 2025Article
- A Case of Unresectable Hepatocellular Carcinoma Treated with Spacer Placement Surgery with Bioabsorbable Spacer and Subsequent Proton Beam Therapy.Surgical case reports · 2025Article
- Impact of cyclophosphamide on the morphological and histological changes in polyglycolic acid spacers.Journal of radiation research · 2024Article
- Feasibility estimation of injected hydrodissection before definitive radiotherapy of pancreatic adenocarcinoma.Journal of the Chinese Medical Association : JCMA · 2024Article
- Hydrogel spacer injection to the meso-sigmoid to protect the sigmoid colon in cervical cancer brachytherapy: A technical report.Journal of contemporary brachytherapy · 2023Article
- MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience.Clinical and translational radiation oncology · 2023Article
- Visualizing Bioabsorbable Spacer Effectiveness by Confirming the Distal-Tail of Carbon-Ion Beams: First-In-Human Report.Tomography (Ann Arbor, Mich.) · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
From August 2019 to August 2020, we inserted polyglycolic acid (PGA) spacers and administered carbon ion radiotherapy (CIRT) to three cases of retroperitoneal sarcoma at our hospital. We aimed to investigate its utility and safety for retroperitoneal sarcoma. We analyzed changes in PGA spacer volume and corresponding computed tomography (CT) values in addition to the dose distribution using in-room CT images that were obtained during treatment. We assessed adverse events and investigated the suitability, safety and effectivity of PGA spacer insertion. During treatment, changes in PGA spacer volumes and CT values were confirmed. Volumes increased in patients with a folded PGA spacer, and it increased 1.6-fold by the end of irradiation compared with planning CT. The CT values decreased by 20-50 Hounsfield units at the end of irradiation compared to the planning CT. Dose distribution evaluation showed that the dose to the gastrointestinal tract adjacent to the tumor was maintained below the tolerable dose, and a sufficient dose was delivered to the target by PGA spacer insertion. One case of subileus caused during abdominal surgery for PGA spacer insertion occurred. No other adverse events, such as digestive disorders, were observed. CIRT with PGA spacer insertion for retroperitoneal sarcomas is safe and effective. For cases in which there is no option but to perform irradiation using a PGA spacer, precautionary measures such as verification of dose distributions using CT images are necessary.
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