Evidence map›Paper›PMID 35151523›Full record

SynthesisAmerican journal of preventive medicine2022

Interventions for Reversing Prediabetes: A Systematic Review and Meta-Analysis.

Karla I Galaviz, Mary Beth Weber, Kara Suvada, Unjali P Gujral, Jingkai Wei, Rozina Merchant, Sahrudh Dharanendra, J Sonya Haw, K M Venkat Narayan, Mohammed K Ali

2 registry-linked trialsOpen access · greenAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of preventive medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 78 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 9 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06064669 narecruitingstarted 2024, after this paper: background citation

Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial

Ran2024Enrolled988Registered outcomes26Posted comparisons0ConditionsIn-Vitro Fertilization, Metformin, PrediabetesArmsMetformin pretreatment before endometrial preparation for frozen embryo transfer, Metformin pretreatment before ovarian stimulation, Placebo pretreatment before endometrial preparation for frozen embryo transfer, Placebo pretreatment before ovarian stimulation
PMID 34281467PMID 25945500PMID 29045765PMID 18826999PMID 11832527PMID 9096977PMID 8732721PMID 36916886PMID 36720508PMID 36507649PMID 36497026PMID 36396532other papers from this trial
Open the trial in the graph
NCT06236334 nacompletednot on this mapstarted 2024, after this paper: background citation

The Validation of a Proof-of-concept Study of People at Risk for Diabetes With Personalised Lifestyle Interventions and E-health to Change Lifestyle Behaviour and Reverse the Risk for Diabetes

TypeinterventionalSponsorTNORan2024 to 2024Enrolled9ConditionsPre-diabetesArmsELFI lifestyle intervention
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 9 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Pooled it
  5. Pooled it
  6. Lower-Intensity Interventions for Prediabetes: A Systematic Review.American journal of preventive medicine · 2023
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Review
  12. Article
  13. Article
  14. [Obesity and type 2 diabetes mellitus (Update 2026)].Wiener klinische Wochenschrift · 2026
    Review
  15. Article
  16. Article
  17. Modern Management of CKM Syndrome: Use of GLP-1 Receptor Agonists in a Multidisciplinary Setting-Expert Group Recommendations from Kuwait.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Karla I GalavizFrom the Department of Applied Health Science, School of Public Health, Indiana University Bloomington, Bloomington, Indiana. Electronic address: kgalaviz@iu.edu.
Mary Beth WeberHubert Department of Global Health (HDGH), Rollins School of Public Health, Emory University, Atlanta, Georgia.
Kara SuvadaHubert Department of Global Health (HDGH), Rollins School of Public Health, Emory University, Atlanta, Georgia.
Unjali P GujralHubert Department of Global Health (HDGH), Rollins School of Public Health, Emory University, Atlanta, Georgia.
Jingkai WeiDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
Rozina MerchantDepartment of Family and Preventime Medicine and the Emory University School of Medicine, Atlanta, Georgia.
Sahrudh DharanendraHubert Department of Global Health (HDGH), Rollins School of Public Health, Emory University, Atlanta, Georgia.
J Sonya HawDepartment of Family and Preventime Medicine and the Emory University School of Medicine, Atlanta, Georgia.
K M Venkat NarayanHubert Department of Global Health (HDGH), Rollins School of Public Health, Emory University, Atlanta, Georgia; Department of Family and Preventime Medicine and the Emory University School of Medicine, Atlanta, Georgia.
Mohammed K AliHubert Department of Global Health (HDGH), Rollins School of Public Health, Emory University, Atlanta, Georgia; Department of Family and Preventime Medicine and the Emory University School of Medicine, Atlanta, Georgia.
Emory University · USIndiana University Bloomington · USUniversity of South Carolina · US

Funding

Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Worksite Lifestyle Program for Reducing Diabetes and Cardiovascular Risk in IndiaR01HL125442 · NHLBI · EMORY UNIVERSITY · PI PRABHAKARAN, DORAIRAJ, WEBER, MARY BETH · 2015 to 2019
$3.3M
Cost-effectiveness of cardiovascular disease prevention in HIV care: a systems science approachK01HL149479 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI GALAVIZ, KARLA IVETTE · 2019 to 2023
$638k
NHLBI NIH HHS K01 HL149479NHLBI NIH HHS R01 HL125442NIDDK NIH HHS P30 DK111024
6 · The paper itself

Abstract

introductionSeveral interventions have been found to be effective for reversing prediabetes in adults. This systematic review and meta-analysis aims to compare the effectiveness of such interventions.

methodsMEDLINE, Embase, and Cochrane Library databases were searched for articles published between January 1, 2000 and June 27, 2018. RCTs in adults with prediabetes, testing nonsurgical interventions lasting for ≥3 months, and reporting the number of participants achieving normal glucose levels at intervention end were eligible. The pooled risk difference and number needed to treat for achieving normoglycemia were estimated using a random-effects, arm-based network meta-analysis. The strength of the evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation. Data were obtained in 2018 and analyzed in 2019 and 2021.

resultsOf 54 studies included in the systematic review, 47 were meta-analyzed (n=26,460, mean age=53 years, 46% male, 31% White). Studies included 27 arms testing lifestyle modification interventions, 25 testing medications, 5 testing dietary supplements, and 10 testing Chinese medicine. There were 35 control/placebo arms. At a median follow-up of 1.6 years, more participants in the lifestyle modification groups achieved normoglycemia than those in the control (risk difference=0.18, number needed to treat=6). The strength of the evidence was strong for lifestyle modification. Over a median follow-up of 2.7 years, more participants receiving glucagon-like peptide-1 receptor agonists (risk difference=0.47, number needed to treat=2), α-glucosidase inhibitors (risk difference=0.29, number needed to treat=4), and insulin sensitizers (risk difference=0.23, number needed to treat=4) achieved normoglycemia than control. The strength of evidence was moderate for these medications. DISCUSSION: Although several pharmacological approaches can reverse prediabetes, lifestyle modification provides the strongest evidence of effectiveness and should remain the recommended approach to address this condition.

Indexed as

Prediabetic StateAdultFemaleHumansLife StyleMaleMiddle Aged

Identifiers

PMID35151523
PMCPMC10420389
OpenAlexW4211246171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.