SynthesisCancer imaging : the official publication of the International Cancer Imaging Society2022
Determining the elastography strain ratio cut off value for differentiating benign from malignant breast lesions: systematic review and meta-analysis.
Synthesis in Cancer imaging : the official publication of the International Cancer Imaging Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07649590 (Diagnostic Value of Strain Elastography in Characterization of Solid Breast Lesions.), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostic Value of Strain Elastography in Characterization of Solid Breast Lesions.
Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- The value of multi-parametric ultrasonography nomogram in predicting nipple-areolar complex involvement in breast cancer.Quantitative imaging in medicine and surgery · 2026Article
- Evaluation of diagnostic accuracy and molecular adequacy between conventional endobronchial ultrasound, contrast-enhanced endobronchial ultrasound and elastography for hilar and mediastinal lymphadenopathies: a retrospective observational study.Journal of thoracic disease · 2026Article
- Article
- An innovative approach for predicting prostate cancer Gleason grading: machine learning-based fusion of multimodal ultrasound, clinical and laboratory indicators.European journal of medical research · 2025Article
- Multi-center strain elastography radiomics for breast cancer diagnosis: integrating intratumoral and peritumoral regions.Discover oncology · 2025Article
- A combined clinical-ultrasound radiomics model for differentiating benign and malignant BI-RADS category 4 breast masses.American journal of translational research · 2025Article
- MixTURE: L1-Norm-Based Mixed Second-Order Continuity in Strain Tensor Ultrasound Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Downgrading Breast Imaging Reporting and Data System categories in ultrasound using strain elastography and computer-aided diagnosis system: a multicenter, prospective study.The British journal of radiology · 2024Article
- Strain Elastography Fat-to-Lesion Index Is Associated with Mammography BI-RADS Grading, Biopsy, and Molecular Phenotype in Breast Cancer.Biosensors · 2024Article
- Translating new breast ultrasound techniques into clinical practice: evaluating their intended uses and describing other unexpected uses for them.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2023Review
- Strain sonoelastography in asymptomatic individuals and individuals with knee osteoarthritis: an evaluation of quadriceps and patellar tendon.Rheumatology international · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElastography is an addition to grey-scale ultrasonic examination that has gained substantial traction within the last decade. Strain ratio (SR) has been incorporated as a semiquantitative measure within strain elastography, thus a potential imaging biomarker. The World Federation for Ultrasound in Medicine and Biology (WFUMB) published guidelines in 2015 for breast elastography. These guidelines acknowledge the marked variance in SR cut-off values used in differentiating benign from malignant lesions. The objective of this review was to include more recent evidence and seek to determine the optimal strain ratio cut off value for differentiating between benign and malignant breast lesions.
methodsComprehensive search of MEDLINE and Web of Science electronic databases with additional searches via Google Scholar and handsearching set from January 2000 to May 2020 was carried out. For retrieved studies, screening for eligibility, data extraction and analysis was done as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Diagnostic Test Accuracy (PRISMA-DTA) Statement guidelines of 2018. Quality and risk of bias assessment of the studies were performed using the revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool.
resultsA total of 424 articles, 412 from electronic database and 12 additional searches were retrieved and 65 studies were included in the narrative synthesis and subgroup analysis. The overall threshold effect indicated significant heterogeneity among the studies with Spearman correlation coefficient of Logit (TPR) vs Logit (FPR) at - 0.301, p-value = 0.015. A subgroup under machine model consisting seven studies with 783 patients and 844 lesions showed a favourable threshold, Spearman's correlation coefficient,0.786 (p = 0.036).
conclusionFrom our review, currently the optimal breast SR cut-off point or value remains unresolved despite the WFUMB guidelines of 2015. Machine model as a possible contributor to cut-off value determination was suggested from this review which can be subjected to more industry and multi-center research determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.