Observational studyBMC anesthesiology2022
Association between circadian variation of heart rate and mortality among critically ill patients: a retrospective cohort study.
Observational study in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Temporal distribution of recorded intensive care unit deaths across the 24-hour cycle: a 15-year retrospective hospital-based study.BMC anesthesiology · 2026Observational
- Mediating Effect of Depression on Relationship Between Sleep Disturbance and Locomotive Syndrome in Geriatric Cancer Patients.Journal of multidisciplinary healthcare · 2026Article
- Exploring the Relationship Between Continuously Monitored Vital Signs, Clinical Deterioration, and Clinical Actions.Journal of clinical medicine · 2025Article
- Optimizing clinical prediction model for new-onset atrial fibrillation in critically ill patient: Based on machine learning.PloS one · 2025Article
- The search for optimal nocturnal diurnal heart rate Index targets in ICU patients: a retrospective observational study from large ICU database.Frontiers in cardiovascular medicine · 2024Article
- Evaluation of circadian rhythm and prognostic variability pre-and post-CEA or CAS treatment in patients with carotid artery stenosis.Frontiers in neurology · 2024Article
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8 authors.
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Abstract
backgroundHeart rate (HR) related parameters, such as HR variability, HR turbulence, resting HR, and nighttime mean HR have been recognized as independent predictors of mortality. However, the influence of circadian changes in HR on mortality remains unclear in intensive care units (ICU). The study is designed to evaluate the relationship between the circadian variation in HR and mortality risk among critically ill patients.
methodsThe present study included 4,760 patients extracted from the Multiparameter Intelligent Monitoring in Intensive Care II database. The nighttime mean HR/daytime mean HR ratio was adopted as the circadian variation in HR. According to the median value of the circadian variation in HR, participants were divided into two groups: group A (≤ 1) and group B (> 1). The outcomes included ICU, hospital, 30-day, and 1-year mortalities. The prognostic value of HR circadian variation was investigated by multivariable logistic regression models and Cox proportional hazards models.
resultsPatients in group B (n = 2,471) had higher mortality than those in group A (n = 2,289). Multivariable models revealed that the higher circadian variation in HR was associated with ICU mortality (odds ratio [OR], 1.393; 95% confidence interval [CI], 1.112-1.745; P = 0.004), hospital mortality (OR, 1.393; 95% CI, 1.112-1.745; P = 0.004), 30-day mortality (hazard ratio, 1.260; 95% CI, 1.064-1.491; P = 0.007), and 1-year mortality (hazard ratio, 1.207; 95% CI, 1.057-1.378; P = 0.005), especially in patients with higher SOFA scores.
conclusionsThe circadian variation in HR might aid in the early identification of critically ill patients at high risk of associated with ICU, hospital, 30-day, and 1-year mortalities.
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