ArticleBMC genomics2022
Genome-wide identification and expression profiling analysis of maize AP2/ERF superfamily genes reveal essential roles in abiotic stress tolerance.
Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 79 citations in OpenAlex.
- Integrative Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanisms of Leaf Rust Resistance inBiology · 2026Article
- Identification of salt and drought resistance function of maize transcription factor ZmEREB54.BMC plant biology · 2026Article
- Genome-wide identification and characterization of the glutaredoxin (GRX) family genes in wild soybean and their expression dynamics under salt and alkali conditions.Molecular biology reports · 2026Article
- Characterization of the AP2/ERF gene family in Fritillaria thunbergii and functional evaluation of FtAP2/ERF-61 in conferring tolerance to drought and salt stress.BMC plant biology · 2026Article
- Genome-wide identification and expression profiling of the ERF subfamily in Polygala tenuifolia seedlings under drought stress.BMC plant biology · 2026Article
- The TaERF3-Plants (Basel, Switzerland) · 2026Article
- Identification and characterization of the DREB family in Chinese yam and functional study of DoDREB28 under drought stress.BMC plant biology · 2026Article
- Comprehensive Analysis of the AP2/ERF Superfamily Identifies Key Genes Related to Various Stress Responses in Olive Tree (Current issues in molecular biology · 2026Article
- Genome- and Transcriptome-Wide Characterization of AP2/ERF Transcription Factor Superfamily Reveals Their Relevance inPlants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of Alfalfa AP2/ERF gene family and abiotic stress response.Frontiers in plant science · 2026Article
- Comprehensive characterization of the genes in AP2/ERF family and their involvement in salt-alkali stress response duringFrontiers in plant science · 2026Article
- Identification and analysis of the AP2/ERF gene family inFrontiers in plant science · 2026Article
- Genome-wide identification and characterization of the AP2/ERF gene family in Cinnamomum camphora.BMC genomics · 2025Article
- Genome-wide analysis of the AP2/ERF transcription factor superfamily in perennial ryegrass.BMC genomics · 2025Article
- Comprehensive analysis of the sucrose nonfermenting 1-related protein kinase 2 gene family in broomcorn millet (Panicum miliaceum L.) under abiotic stress conditions.BMC genomics · 2025Article
- Genome-wide identification of peanut ERFs and functional characterization of AhERF28 in response to salt and drought stresses.Plant cell reports · 2025Article
- The Role of AP2/ERF Transcription Factors in Plant Responses to Biotic Stress.International journal of molecular sciences · 2025Review
- Transcriptome Analysis Reveals the Pivotal Genes and Regulation Pathways Under Cold Stress and IdentifiesPlants (Basel, Switzerland) · 2025Article
- Mechanism Analysis ofInternational journal of molecular sciences · 2025Article
- Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize.BMC plant biology · 2025Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundAs one of the largest transcription factor families in plants, the APETALA2/Ethylene-Responsive Factor (AP2/ERF) superfamily is involved in various biological processes and plays significant roles in plant growth, development and responses to various stresses. Although identification and characterization of AP2/ERF superfamily genes have been accomplished in many plant species, very little is known regarding the structure and function of AP2/ERF genes in maize.
resultsIn this study, a total of 214 genes encoding ZmAP2/ERF proteins with complete AP2/ERF domain were eventually identified according to the AGPv4 version of the maize B73 genome. Based on the number of AP2/ERF domain and similarities of amino acid sequences among AP2/ERF proteins from Arabidopsis, rice and maize, all 214 putative ZmAP2/ERF proteins were categorized into three distinct families, including the AP2 family (44), the ERF family (166) and the RAV family (4), respectively. Among them, the ERF family was further subdivided into two diverse subfamilies, including the DREB and ERF subfamilies with 61 and 105 members, respectively. Further, based on phylogenetic analysis, the members of DREB and ERF subfamilies were subdivided into four (Group I-IV) and eight (Group V-XII) groups, respectively. The characteristics of exon-intron structure of these putative ZmAP2/ERF genes and conserved protein motifs of their encoded ZmAP2/ERF proteins were also presented respectively, which was in accordance with the results of group classification. Promoter analysis suggested that ZmAP2/ERF genes shared many stress- and hormone-related cis-regulatory elements. Gene duplication and synteny analysis revealed that tandem or segmental duplication and purifying selection might play significant roles in evolution and functional differentiation of AP2/ERF superfamily genes among three various gramineous species (maize, rice and sorghum). Using RNA-seq data, transcriptome analysis indicated that the majority of ZmAP2/ERF genes displayed differential expression patterns at different developmental stages of maize. In addition, the following analyses of co-expression network among ZmAP2/ERF genes and protein protein interaction between ZmAP2 and ZmERF proteins further enabled us to understand the regulatory relationship among members of the AP2/ERF superfamily in maize. Furthermore, by quantitative real-time PCR analysis, twenty-seven selected ZmAP2/ERF genes were further confirmed to respond to three different abiotic stresses, suggesting their potential roles in various abiotic stress responses. Collectively, these results revealed that these ZmAP2/ERF genes play essential roles in abiotic stress tolerance.
conclusionsTaken together, the present study will serve to present an important theoretical basis for further exploring the function and regulatory mechanism of ZmAP2/ERF genes in the growth, development, and adaptation to abiotic stresses in maize.
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