Evidence map›Paper›PMID 35151216›Full record

ArticleJournal of psychiatric research2022

Investigating the relationships between resilience, autism-related quantitative traits, and mental health outcomes among adults during the COVID-19 pandemic.

Sara C Taylor, Zoe L Smernoff, Maya Rajan, Samantha Steeman, Brielle N Gehringer, Holly C Dow, Ran Barzilay, Daniel J Rader, Maja Bucan, Laura Almasy and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 27 citations in OpenAlex.

  1. Sleep and activity patterns in autism.Autism : the international journal of research and practice · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sara C TaylorDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA; Neuroscience Graduate Group, Perelman School of Medicine at the University of Pennsylvania, 140 John Morgan Bldg., 3620 Hamilton Walk, Philadelphia, PA, 19104-6074, USA.
Zoe L SmernoffDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Maya RajanDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Samantha SteemanDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Brielle N GehringerDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Holly C DowDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Ran BarzilayDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA; Lifespan Brain Institute, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Daniel J RaderDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Maja BucanDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA.
Laura AlmasyDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA, 19104-6145, USA; Lifespan Brain Institute, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Edward S BrodkinDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Translational Research Laboratory, 125 South 31st Street, Philadelphia, PA, 19104-3403, USA. Electronic address: ebrodkin@pennmedicine.upenn.edu.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USTranslational Therapeutics (United States) · US

Funding

Investigating the Genetic Basis for Quantitative Autistic Spectrum Disorder (ASD) TraitsF31MH125539 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI TAYLOR, SARA · 2021 to 2021
$44k
NIMH NIH HHS F31 MH125539
6 · The paper itself

Abstract

Resilience is a dynamic process through which people adjust to adversity and buffer anxiety and depression. The COVID-19 global pandemic has introduced a shared source of adversity for people across the world, with detrimental implications for mental health. Despite the pronounced vulnerability of autistic adults to anxiety and depression during the COVID-19 pandemic, relationships among autism-related quantitative traits, resilience, and mental health outcomes have not been examined. As such, we aimed to describe the relationships between these traits in a sample enriched in autism spectrum-related quantitative traits during the COVID-19 pandemic. We also aimed to investigate the impact of demographic and social factors on these relationships. Across three independent samples of adults, we assessed resilience factors, autism-related quantitative traits, anxiety symptoms, and depression symptoms during the COVID-19 pandemic. One sample (recruited via the Autism Spectrum Program of Excellence, n = 201) was enriched for autism traits while the other two (recruited via Amazon Mechanical Turk, n = 624 and Facebook, n = 929) drew from the general population. We found resilience factors and quantitative autism-related traits to be inversely related, regardless of the resilience measure used. Additionally, we found that resilience factors moderate the relationship between autism-related quantitative traits and depression symptoms such that resilience appears to be protective. Across the neurodiversity spectrum, resilience factors may be targets to improve mental health outcomes. This approach may be especially important during the ongoing COVID-19 pandemic and in its aftermath.

Indexed as

Autistic DisorderCOVID-19AdultAnxietyDepressionHumansOutcome Assessment, Health CarePandemicsSARS-CoV-2AdultsAnxietyAutism spectrumCOVID-19 pandemicDepressionResilience

Identifiers

PMID35151216
PMCPMC8799379
OpenAlexW4210522766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.