ArticleNeuroImage2022
Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- ApoE expression across the CNS: Who, What, Where, When, and How (much)?Molecular neurodegeneration advances · 2026Review
- White matter integrity and motor function: a link between cerebral myelination and longitudinal changes in gait speed in aging.GeroScience · 2025Article
- Investigating the association between human brainstem microstructural integrity and hypertension using magnetic resonance relaxometry.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Change in transverse relaxation rates (RHuman brain mapping · 2025Article
- Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.Journal of neurochemistry · 2024Review
- Multifaceted roles of APOE in Alzheimer disease.Nature reviews. Neurology · 2024Review
- Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis?CNS neuroscience & therapeutics · 2024Review
- Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study.PloS one · 2024Article
- Cerebral white matter myelination is associated with longitudinal changes in processing speed across the adult lifespan.Brain communications · 2024Article
- REUSED: A deep neural network method for rapid whole-brain high-resolution myelin water fraction mapping from extremely under-sampled MRI.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2023Article
- Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Current Perspectives: Obesity and Neurodegeneration - Links and Risks.Degenerative neurological and neuromuscular disease · 2023Review
- Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics.Translational neurodegeneration · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Mounting evidence indicates that myelin breakdown may represent an early phenomenon in neurodegeneration, including Alzheimer's disease (AD). Understanding the factors influencing myelin synthesis and breakdown will be essential for the development and evaluation of therapeutic interventions. In this work, we assessed associations between genetic variance in apolipoprotein E (APOE) and cerebral myelin content. Quantitative magnetic resonance imaging (qMRI) was performed on a cohort of 92 cognitively unimpaired adults ranging in age from 24 to 94 years. We measured whole-brain myelin water fraction (MWF), a direct measure of myelin content, as well as longitudinal and transverse relaxation rates (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.