Evidence map›Paper›PMID 35150732›Full record

ArticleMetabolism: clinical and experimental2022

Chronic circadian disruption on a high-fat diet impairs glucose tolerance.

Kirsi-Marja Zitting, Ramalingam Vetrivelan, Robin K Yuan, Nina Vujovic, Wei Wang, Sathyajit S Bandaru, Stuart F Quan, Elizabeth B Klerman, Frank A J L Scheer, Orfeu M Buxton and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Sleep and circadian effects on the incretin system.Current sleep medicine reports · 2025
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  8. Natural Compounds for Preventing Age-Related Diseases and Cancers.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Kirsi-Marja ZittingDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Ramalingam VetrivelanDivision of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Robin K YuanDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Nina VujovicDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Wei WangDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Sathyajit S BandaruDivision of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Stuart F QuanDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Elizabeth B KlermanDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Frank A J L ScheerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Orfeu M BuxtonDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Department of Biobehavioral Health, University Park PA 16802, USA.
Jonathan S WilliamsDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jeanne F DuffyDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Clifford B SaperDivision of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Charles A CzeislerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: cacadmin@partners.org.
Harvard University · USBrigham and Women's Hospital · USCircadian (United States) · USBeth Israel Deaconess Medical Center · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1M
TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUXTON, ORFEU M · 1991 to 2018
$23.1M
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Role of Meal Timing in Efficacy of Bariatric Surgery in Obese IndividualsR01HL140574 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A, TAVAKKOLI, ALI · 2017 to 2023
$4.2M
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8M
Influence of sleep regularity on circadian rhythms, learning, performance, and moodR01HL128538 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KLERMAN, ELIZABETH B. · 2016 to 2019
$3.6M
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2M
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep RestrictionR01DK127254 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 2021 to 2024
$3.1M
Meal Time Effects on Metabolic Health.R01DK099512 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.8M
Hypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8M
Development of countermeasures against adverse metabolic effects of shift workR01HL118601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.6M
NCATS NIH HHS UL1 TR002541NHLBI NIH HHS F32 HL143893NHLBI NIH HHS K24 HL105664NHLBI NIH HHS P01 HL095491NHLBI NIH HHS R01 HL118601NHLBI NIH HHS R01 HL128538NHLBI NIH HHS R01 HL140574NHLBI NIH HHS T32 HL007901NIA NIH HHS F32 AG051325NIA NIH HHS P01 AG009975NIA NIH HHS R43 AG056250NIA NIH HHS R44 AG056250NIDDK NIH HHS R01 DK099512NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK127254NIGMS NIH HHS R01 GM105018NIH HHS UL1 TR002541NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS088482NINDS NIH HHS R01 NS119223
6 · The paper itself

Abstract

backgroundNearly 14% of Americans experience chronic circadian disruption due to shift work, increasing their risk of obesity, diabetes, and other cardiometabolic disorders. These disorders are also exacerbated by modern eating habits such as frequent snacking and consumption of high-fat foods.

methodsWe investigated the effects of recurrent circadian disruption (RCD) on glucose metabolism in C57BL/6 mice and in human participants exposed to non-24-h light-dark (LD) schedules vs. those on standard 24-h LD schedules. These LD schedules were designed to induce circadian misalignment between behaviors including rest/activity and fasting/eating with the output of the near-24-h central circadian pacemaker, while minimizing sleep loss, and were maintained for 12 weeks in mice and 3 weeks in humans. We examined interactions of these circadian-disrupted schedules compared to control 24-h schedules with a lower-fat diet (LFD, 13% in mouse and 25-27% in humans) and high-fat diet (HFD, 45% in mouse and 45-50% in humans). We also used young vs. older mice to determine whether they would respond differently to RCD.

resultsWhen combined with a HFD, we found that RCD caused significant weight gain in mice and increased body fat in humans, and significantly impaired glucose tolerance and insulin sensitivity in both mice and humans, but this did not occur when RCD was combined with a LFD. This effect was similar in both young and older mice.

conclusionThese results in both humans and a model organism indicate that circadian disruption has an adverse effect on metabolism among individuals eating a high-fat Western-style diet, even in the absence of significant sleep loss, and suggest that reducing dietary fat may protect against the metabolic consequences of a lifestyle (such as shift work) that involves chronic circadian disruption.

Indexed as

Diet, High-FatInsulinAnimalsGlucoseHumansMiceMice, Inbred C57BLObesityGlucoseInsulinGlucose toleranceHigh-fat dietInsulin sensitivityRecurrent circadian disruptionShift workWeight gain

Identifiers

PMID35150732
PMCPMC11797635
OpenAlexW4211054556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.