ArticleNephrology (Carlton, Vic.)2022
Histological diagnosis from kidney transplant biopsy can contribute to prediction of graft survival.
Article in Nephrology (Carlton, Vic.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Computational pathology model to assess acute and chronic transformations of the tubulointerstitial compartment in renal allograft biopsies.Scientific reports · 2024Article
- Impact of nonspecific allograft biopsy findings in symptomatic kidney transplant recipients.Scientific reports · 2024Article
- From designing minimum data set to developing kidney transplantation registry in Iran.Journal of family medicine and primary care · 2023Article
- Sex-specific time trends of long-term graft survival after kidney transplantation - a registry-based study.Renal failure · 2023Article
- Histological diagnosis from kidney transplant biopsy can contribute to prediction of graft survival.Nephrology (Carlton, Vic.) · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
aimThe primary aim of this study was to in depth examine if the histological findings in a transplanted kidney biopsy can predict the prognosis for the graft and the patient. The secondary aim was to extend knowledge of the impact of time elapsed on biopsy findings.
methodsData from 1462 patients were merged from a kidney transplantation registry and a biopsy registry during 1 January 2007 and 30 September 2017. Kaplan-Meier analysis and multivariate Cox-regression analysis were performed and hazard ratios (HR) with 95% confidence intervals (CI) were presented.
resultsCompared to normal biopsy findings, graft survival after biopsy (gsaBiopsy) was shorter for patients with glomerular diseases (HR 8.2, CI:3.2-21.1), rejections (HR 4.2, CI:1.7-10.3), chronic changes including IFTA (HR 3.2, CI:1.3-8.0), acute tubular injuries (HR 3.0, CI:1.2-7.8), and borderline changes (HR 2.9, CI:1.1-7.6). Sub-analysis of rejections showed shorter gsaBiopsy for chronic TCMR (HR 4.7, CI:1.9-11.3), active ABMR (HR 3.6, CI:1.7-7.7) and chronic ABMR (HR 3.5, CI:2.0-6.0). Patients with TCMR Banff grade II (HR 0.35, CI:0.20-0.63) and grade I (HR 0.52, CI:0.29-0.93) had a better gsaBiopsy compared to all other types of rejections.
conclusionShorter gsaBiopsy was noted in kidneys with glomerular diseases, rejections, acute tubular injuries and borderline changes. TCMR Banff rejections grade I and II were associated with a better prognosis.
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