Evidence map›Paper›PMID 35150480›Full record

ArticleBosnian journal of basic medical sciences2022

Obstructive sleep apnoea patients vs laryngopharyngeal reflux disease: Non-invasive evaluation with NBI and pepsin detection in tears.

Annalisa Pace, Valeria Rossetti, Alessandro Milani, Giannicola Iannella, Salvatore Cocuzza, Antonino Maniaci, Danilo Alunni Fegatelli, Annarita Vestri, Antonio Greco, Marco De Vincentiis and 3 more

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In one paragraph

Article in Bosnian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Annalisa PaceScienze Chirurgiche Department, Sapienza University of Rome, Rome, Italy; Organi di Senso Department, Sapienza University of Rome, Rome, Italy.
Valeria RossettiOrgani di Senso Department, Sapienza University of Rome, Rome, Italy.
Alessandro MilaniOrgani di Senso Department, Sapienza University of Rome, Rome, Italy.
Giannicola IannellaScienze Chirurgiche Department, Sapienza University of Rome, Rome, Italy; Organi di Senso Department, Sapienza University of Rome, Rome, Italy; Otolaryngology, Head-Neck and Oral Surgery Unit, Department of Head-Neck Surgery, Morgagni Pierantoni Hospital, Forlì, Italy.
Salvatore CocuzzaOtorinolaringoiatria Department, University of Catania, Catania, Italy.
Antonino ManiaciOtorinolaringoiatria Department, University of Catania, Catania, Italy.
Danilo Alunni FegatelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Annarita VestriDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Antonio GrecoOrgani di Senso Department, Sapienza University of Rome, Rome, Italy.
Marco De VincentiisOrgani di Senso Department, Sapienza University of Rome, Rome, Italy.
Francesca GiovannettiOrgani di Senso Department, Sapienza University of Rome, Rome, Italy.
Rocco PlaterotiOrgani di Senso Department, Sapienza University of Rome, Rome, Italy.
Giuseppe MagliuloOrgani di Senso Department, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITUniversity of Catania · ITOspedale G.B. Morgagni - L.Pierantoni · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnoea (OSA) and laryngopharyngeal reflux disease (LPR) are two common diseases that lower patients' quality of life. OSA is defined by cyclic events of airflow obstruction that occur during sleep, while LPR is characterized by upper airway inflammatory signs and symptoms due to the return of gastroduodenal gaseous and liquid elements. pH-metry is the gold standard in LPR diagnosis, but considering its invasiveness among other negative traits, questionnaires that catalog symptoms and signs of the disease such as Reflux Symptoms Index (RSI) and Reflux Finding Score (RFS) are preferred. Moreover, LPR can be evaluated by testing the presence of pepsin in tears, and Narrow Band Imaging (NBI) has been introduced for the early diagnosis of larynx oncological disease. This paper aims to test whether LPR is more frequent in OSA patients than in control ones, performing a non-invasive protocol composed of RSI, RFS test (with light vs. NBI techniques), followed by pepsin detection in tears. 68 LPR patients were enrolled in the study (45 with OSA and 23 without OSA). A strong linear relationship between Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) was found, and patients who presented pepsin in tears had higher values of AHI and ODI in comparison to patients without it. Pathological RFS and NBI showed higher values of AHI and ODI in comparison to the control group. Furthermore, pathological RSI showed higher values of AHI and ODI in comparison to the control group. In conclusion, this diagnostic combined non-invasive protocol may be a good method to perform an early diagnosis of LPR.

Indexed as

Laryngopharyngeal RefluxPepsin ASleep Apnea, ObstructiveHumansNarrow Band ImagingQuality of LifeTearsPepsin A

Identifiers

PMID35150480
PMCPMC9392973
OpenAlexW4211161050

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.