ArticleRadiation and environmental biophysics2022
The radiation adaptive response and priming dose influence: the quantification of the Raper-Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations.
Article in Radiation and environmental biophysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 26 citations in OpenAlex.
- Comet assay and antioxidant enzyme as blood biomarkers of low-dose radiation-induced adaptive response.Scientific reports · 2026Article
- Zeocin-Induced Adaptive Response inMolecules (Basel, Switzerland) · 2026Article
- Enhancing Astronaut Resilience: The Role of Elevated ROS in Adapting to Space Radiation.Journal of biomedical physics & engineering · 2026Article
- The impact of long-term low-dose ionizing radiation on human health: risks and protective measures.Frontiers in medicine · 2026Review
- Biomarker dosimetry of acute low level of thermal neutrons and radiation adaptive response effect on rats.Scientific reports · 2024Article
- Health Effects of Ionizing Radiation on the Human Body.Medicina (Kaunas, Lithuania) · 2024Review
- Article
- Adaptive Response in Rat Retinal Cell Cultures Irradiated with γ-rays.International journal of molecular sciences · 2023Article
- Late Effects of Heavy-Ion Space Radiation on Splenocyte Subpopulations and NK Cytotoxic Function.Frontiers in astronomy and space sciences · 2022Article
- Understanding the Radiation Adaptive Response: General Methodology and Theoretical Approaches to the Study of the Radioadaptation Phenomenon.Dose-response : a publication of International Hormesis SocietyArticle
- Adaptive Response: A Scoping Review of Its Implications in Medicine, Space Exploration, and Beyond.Dose-response : a publication of International Hormesis SocietyReview
- Integrating Adaptive Responses Into Hormesis: δ Plot Analysis of the Yonezawa Effect in the Micronucleus Test.Dose-response : a publication of International Hormesis SocietyArticle
- Can Adaptive Response Be Considered in Radiation Risk Assessment?Dose-response : a publication of International Hormesis SocietyArticle
- Adaptive Responses in High-Radiation Environments: Insights From Chernobyl Wildlife and Ramsar Residents.Dose-response : a publication of International Hormesis SocietyReview
- Biophysical Modeling of the Ionizing Radiation Influence on Cells Using the Stochastic (Monte Carlo) and Deterministic (Analytical) Approaches.Dose-response : a publication of International Hormesis SocietyReview
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The priming dose effect, called also the Raper-Yonezawa effect or simply the Yonezawa effect, is a special case of the radiation adaptive response phenomenon (radioadaptation), which refers to: (a) faster repair of direct DNA lesions (damage), and (b) DNA mutation frequency reduction after irradiation, by applying a small priming (conditioning) dose prior to the high detrimental (challenging) one. This effect is observed in many (but not all) radiobiological experiments which present the reduction of lesion, mutation or even mortality frequency of the irradiated cells or species. Additionally, the multi-parameter model created by Dr. Yonezawa and collaborators tried to explain it theoretically based on experimental data on the mortality of mice with chronic internal irradiation. The presented paper proposes a new theoretical approach to understanding and explaining the priming dose effect: it starts from the radiation adaptive response theory and moves to the three-parameter model, separately for two previously mentioned situations: creation of fast (lesions) and delayed damage (mutations). The proposed biophysical model was applied to experimental data-lesions in human lymphocytes and chromosomal inversions in mice-and was shown to be able to predict the Yonezawa effect for future investigations. It was also found that the strongest radioadaptation is correlated with the weakest cellular radiosensitivity. Additional discussions were focussed on more general situations where many small priming doses are used.
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