ArticleJournal of clinical laboratory analysis2022
Preparation of chemically stable allergen-specific sublingual immunotherapy from Egyptian allergens.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- Immune Reactivity to Raw and Processed Foods and Their Possible Contributions to Autoimmunity.Foods (Basel, Switzerland) · 2025Review
- Nondaily dosing schedule of allergen-specific sublingual immunotherapy: efficacy and safety.Clinical and experimental vaccine research · 2023Article
- Preparation of chemically stable allergen-specific sublingual immunotherapy from Egyptian allergens.Journal of clinical laboratory analysis · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe term "allergen extracts" refers to solutions of proteins or glycoproteins extracted from source raw materials.
objectivesThis study was planned to prepare chemically stable sublingual immunotherapy from different allergens in Egypt.
methodsAllergen extraction from raw materials. The concentrated aqueous extract of each allergen was mixed with an equal volume of glycerol. The protein content of the preparations was determined using the modified Lowry assay method. The prepared allergens were stored for 9 months at 2-4°C. Samples were analyzed periodically (0, 3, 6, and 9 months of intervals) adopting the Lowry Assay method. Levels of specific IgE to Chenopodium album antigens were measured in patients' sera by ELISA.
resultsThe concentration of all prepared allergens, as indicated by the concentration of the protein content, was found to decrease exponentially with time, implying first-order kinetics of degradation. From the values of the slopes of the log plot for each allergen, the half-life time (t
conclusionDifferences exist among allergen extracts made by multiple manufacturers. So, developments in studies on allergen preparation and characterization in a different locality are necessary.
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Registered trials
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