Evidence map›Paper›PMID 35149957›Full record

ArticleNeuromolecular medicine2022

Bim Deletion Reduces Functional Deficits Following Ischemic Stroke in Association with Modulation of Apoptosis and Inflammation.

Jason A Glab, Hamsa Puthalakath, Shenpeng R Zhang, Antony Vinh, Grant R Drummond, Christopher G Sobey, T Michael De Silva, Hyun Ah Kim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromolecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jason A GlabLa Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia.
Hamsa PuthalakathLa Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia.
Shenpeng R ZhangDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, 3086, Australia.
Antony VinhDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, 3086, Australia.
Grant R DrummondDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, 3086, Australia.
Christopher G SobeyDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, 3086, Australia. C.Sobey@latrobe.edu.au.ORCID 0000-0001-6525-9097
T Michael De Silva *Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, 3086, Australia.
Hyun Ah Kim *Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora, VIC, 3086, Australia.
La Trobe University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular apoptosis is a key pathological mechanism contributing to neuronal death following ischemic stroke. The pro-apoptotic Bcl-2 family protein, Bim, is an important regulator of apoptosis. In this study we investigated the effect of Bim expression on post-stroke functional outcomes, brain injury and inflammatory mechanisms. Wild type (WT) and Bim-deficient mice underwent 1-h middle cerebral artery occlusion (MCAO) followed by 23 h of reperfusion. At 24-h post-stroke, we assessed functional deficit, infarct volume, immune cell death, as well as the number of infiltrating immune cells in the brain and circulating immune cells. Bim deficiency did not affect infarct volume (P > 0.05), but resulted in less motor impairment (~ threefold greater latency to fall in hanging grip strength test, P < 0.05) and a lower median clinical score than WT mice (P < 0.05). Additionally following MCAO, Bim-deficient mice exhibited fewer myeloid cells (particularly neutrophils) in the ischemic brain hemisphere and less apoptosis of CD3

Indexed as

Bcl-2-Like Protein 11Brain IschemiaIschemic StrokeAnimalsApoptosisBrainGene DeletionInfarction, Middle Cerebral ArteryInflammationMiceMice, Inbred C57BLBcl2l11 protein, mouseBcl-2-Like Protein 11ApoptosisInflammationMiddle cerebral artery occlusionMouseStroke

Identifiers

PMID35149957
PMCPMC9684233
OpenAlexW4211068593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.