ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2022
Comparison effects of platelet-rich plasma on healing of infected and non-infected excision wounds by the modulation of the expression of inflammatory mediators: experimental research.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- The synergistic effects of linalool and chitosan-carbon nanotubes enhance the healing of infectious wounds.Scientific reports · 2025Article
- RETRACTED: The effect of biosynthesized silver nanoparticles on Pseudomonas aeruginosa-infected dogs wounds.PloS one · 2025Article
- Facile fabrication of carboxymethylcellulose/ZnO/g-C3N4 containing nutmeg extract with photocatalytic performance for infected wound healing.Scientific reports · 2023Article
- Acceleration in healing of infected full-thickness wound with novel antibacterial γ-AlOOH-based nanocomposites.Progress in biomaterials · 2023Article
- Review on risk factors, classification, and treatment of sternal wound infection.Journal of cardiothoracic surgery · 2023Review
- Article
- The Efficiency and Safety of Platelet-Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of personalized medicine · 2023Review
- Antibacterial and antioxidant double-layered nanofibrous mat promotes wound healing in diabetic rats.Scientific reports · 2023Article
- Locally Injected Autologous Platelet-Rich Plasma Improves Cutaneous Wound Healing in Cats.Animals : an open access journal from MDPI · 2022Article
- Biofabrication of ZnO/Malachite nanocomposite and its coating with chitosan to heal infectious wounds.Scientific reports · 2022Article
- The Effect of Plasma on Bacteria and Normal Cells in Infected Wound.Oxidative medicine and cellular longevity · 2022Article
- Chlorite-Oxidized Oxyamylose (COAM) Has Antibacterial Activity and Positively Affects Skin Wound Healing.Journal of inflammation research · 2022Article
- A Platelet-Rich Plasma-Derived Biologic ClearsFrontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMicrobial invasion in soft tissue is believed to cause infectious wounds and increase healthcare costs, anxiety, and distress. The current study was conducted to evaluate the effects of topical use of platelet-rich plasma (PRP) on infected wound-healing process in rats.
methodsFollowing the induction of a circular wound, the animals were divided into three groups, including (1) standard control: infected wounds treated with mupirocin (SDCL), (2) non-infected wounds treated with PRP (PRP), and (3) infected group in which the rats were infected with Staphylococcus epidermidis and Pseudomonas aeruginosa and treated with PRP (INF + PRP). To evaluate the effects of PRP on the wound-healing rate, total bacterial count, histopathological assessment, the serum concentrations of sialic acid, C-reactive protein, haptoglobin, and fibrinogen were assessed. Additionally, IL-1β, IL-6, TNF-α, IL-3, NF-κB, iNOS, PDGF, and EGF mRNA level expressions were assessed employing the qRT-PCR method.
resultsThe results indicated that topical application of PRP could significantly decrease total bacterial count, the level of C-reactive protein, and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) compared to the SDCL group. The administration of PRP also promoted re-epithelization rate by increasing the expression of EGF mRNA level.
conclusionWe could recommend the use of PRP for the treatment of infected wounds owing to its efficiency in decreasing colonization of tissue bacteria, tissue inflammation, and stimulating wound heal-up.
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