Evidence map›Paper›PMID 35149715›Full record

ArticleNature communications2022

Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe.

Lizhu Li, Lihui Lu, Yuqi Ren, Guo Tang, Yu Zhao, Xue Cai, Zhao Shi, He Ding, Changbo Liu, Dali Cheng and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Mechanically adaptive and deployable intracortical probes enable long-term neural electrophysiological recordings.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. A silicon diode-based optoelectronic interface for bidirectional neural modulation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Practical considerations in an era of multicolor optogenetics.Frontiers in cellular neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Lizhu Li *Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
Lihui Lu *Chinese Institute for Brain Research, Beijing, China.
Yuqi Ren *Chinese Institute for Brain Research, Beijing, China.
Guo Tang *Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
Yu ZhaoDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
Xue CaiDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
Zhao ShiDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
He DingSchool of Optics and Photonics, Beijing Institute of Technology, Beijing, China.ORCID http://orcid.org/0000-0002-0884-3112
Changbo LiuSchool of Materials Science and Engineering, Beihang University, Beijing, China.
Dali ChengDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
Yang XieDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
Huachun WangDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China.
Xin FuSchool of Materials Science and Engineering, Tsinghua University, Beijing, China.
Lan YinSchool of Materials Science and Engineering, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0001-7306-4628
Minmin LuoChinese Institute for Brain Research, Beijing, China. luominmin@cibr.ac.cn.ORCID http://orcid.org/0000-0003-3535-6624
Xing ShengDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China. xingsheng@tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-8744-1700
Tsinghua University · CNMcGovern Institute for Brain Research · USNational Institute of Biological Sciences, Beijing · CNBeihang University · CNBeijing Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optogenetic methods provide efficient cell-specific modulations, and the ability of simultaneous neural activation and inhibition in the same brain region of freely moving animals is highly desirable. Here we report bidirectional neuronal activity manipulation accomplished by a wireless, dual-color optogenetic probe in synergy with the co-expression of two spectrally distinct opsins (ChrimsonR and stGtACR2) in a rodent model. The flexible probe comprises vertically assembled, thin-film microscale light-emitting diodes with a lateral dimension of 125 × 180 µm

Indexed as

Behavior, AnimalWireless TechnologyAnimalsBrainDopamineDopaminergic NeuronsMaleMiceMice, Inbred C57BLOpsinsOptogeneticsVentral Tegmental AreaDopamineOpsins

Identifiers

PMID35149715
PMCPMC8837785
OpenAlexW4211223838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.