ArticleNature communications2022
Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A computational framework for epigenetic plasticity in memory.Brain : a journal of neurology · 2026Review
- Role of the hippocampus in systems consolidation of remote fear memory.Experimental & molecular medicine · 2026Review
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Repetition dynamically and rapidly increases cortical, but not hippocampal, offline reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Memory's gatekeeper: The role of PFC in the encoding of congruent events.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dynamic and selective engrams emerge with memory consolidation.Nature neuroscience · 2024Article
- Anatomically distributed neural representations of instincts in the hypothalamus.bioRxiv : the preprint server for biology · 2023Article
- Engram stability and maturation during systems consolidation.Current biology : CB · 2023Article
- Hippocampal memory reactivation during sleep is correlated with specific cortical states of the retrosplenial and prefrontal cortices.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Effects of prior knowledge on brain activation and functional connectivity during memory retrieval.Scientific reports · 2023Article
- Article
- Anteromedial Thalamus Gates the Selection & Stabilization of Long-Term Memories.bioRxiv : the preprint server for biology · 2023Article
- A model of autonomous interactions between hippocampus and neocortex driving sleep-dependent memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- Hebbian plasticity in parallel synaptic pathways: A circuit mechanism for systems memory consolidation.PLoS computational biology · 2021Article
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3 authors.
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Abstract
Systems consolidation refers to the time-dependent reorganization of memory representations or engrams across brain regions. Despite recent advancements in unravelling this process, the exact mechanisms behind engram dynamics and the role of associated pathways remain largely unknown. Here we propose a biologically-plausible computational model to address this knowledge gap. By coordinating synaptic plasticity timescales and incorporating a hippocampus-thalamus-cortex circuit, our model is able to couple engram reactivations across these regions and thereby reproduce key dynamics of cortical and hippocampal engram cells along with their interdependencies. Decoupling hippocampal-thalamic-cortical activity disrupts systems consolidation. Critically, our model yields testable predictions regarding hippocampal and thalamic engram cells, inhibitory engrams, thalamic inhibitory input, and the effect of thalamocortical synaptic coupling on retrograde amnesia induced by hippocampal lesions. Overall, our results suggest that systems consolidation emerges from coupled reactivations of engram cells in distributed brain regions enabled by coordinated synaptic plasticity timescales in multisynaptic subcortical-cortical circuits.
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