Evidence map›Paper›PMID 35149529›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Circulating T Cells Are Not Sufficient for Protective Immunity against Virulent

Lydia M Roberts, Tara D Wehrly, Ian Leighton, Patrick Hanley, Jamie Lovaglio, Brian J Smith, Catharine M Bosio

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lydia M RobertsImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT; and.
Tara D WehrlyImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT; and.
Ian LeightonImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT; and.
Patrick HanleyRocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT.ORCID 0000-0003-2300-1818
Jamie LovaglioRocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT.ORCID 0000-0002-7567-446X
Brian J SmithRocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT.
Catharine M BosioImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT; and bosioc@niaid.nih.gov.
National Institutes of Health · USRocky Mountain Institute · US

Funding

Veterinary Services Core for Infectious Diseases Research- RMLZIGAI001048 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HANLEY, PATRICK · 2009 to 2025
$135.0M
Immunity to Pulmonary InfectionsZIAAI001013 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BOSIO, CATHARINE · 2009 to 2025
$18.9M
Animal Research Support of COVID StudiesZICAI001330 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HANLEY, PATRICK · 2020 to 2022
$3.2M
Immunity to Pneumonic TularemiaZ01AI001013 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BOSIO, CATHARINE · 2007 to 2008
$2.8M
Intramural NIH HHS Z01 AI001013
6 · The paper itself

Abstract

Pulmonary infections elicit a combination of tissue-resident and circulating T cell responses. Understanding the contribution of these anatomically distinct cellular pools in protective immune responses is critical for vaccine development.

Indexed as

AnimalsAntibodies, BacterialBacterial LoadBacterial VaccinesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleFrancisella tularensisLeukocyte Common AntigensLung DiseasesMemory T CellsMiceMice, Inbred C57BLTularemiaVaccinationAntibodies, BacterialBacterial VaccinesLeukocyte Common AntigensPtprc protein, mouse

Identifiers

PMID35149529
PMCPMC8881340
OpenAlexW4211169555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.