ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Integrated Amygdala, Orbitofrontal and Hippocampal Contributions to Reward and Loss Coding Revealed with Human Intracranial EEG.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Distinct neurobiological alterations during hedonic experience of rewards in attention deficit hyperactivity disorder and autism spectrum disorder: Multimodal evidence from neuroimaging meta-analyses.Molecular psychiatry · 2026Pooled it
- Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study.Cell reports. Medicine · 2023Trial
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Structural brain differences in school-aged children who are HIV-exposed uninfected.BMC medicine · 2025Article
- Representation of Anticipated Rewards and Punishments in the Human Brain.Annual review of psychology · 2025Review
- Reward recalibrates rule representations in human amygdala and hippocampus intracranial recordings.Nature communications · 2024Article
- Subthalamic stimulation causally modulates human voluntary decision-making to stay or go.NPJ Parkinson's disease · 2024Article
- Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex.Current biology : CB · 2024Article
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception.Nature communications · 2024Article
- More widespread and rigid neuronal representation of reward expectation underlies impulsive choices.bioRxiv : the preprint server for biology · 2024Article
- Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making.bioRxiv : the preprint server for biology · 2023Article
- Electrophysiological signatures of inequity-dependent reward encoding in the human OFC.Cell reports · 2023Article
- Risk and aversion coding in human habenula high gamma activity.Brain : a journal of neurology · 2023Article
- Analysis of brain signal change response in amygdala evoked by skin pressure stimulus.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Neurophysiological work in primates and rodents have shown the amygdala plays a central role in reward processing through connectivity with the orbitofrontal cortex (OFC) and hippocampus. However, understanding the role of oscillations in each region and their connectivity in different stages of reward processing in humans has been hampered by limitations with noninvasive methods such as poor spatial and temporal resolution. To overcome these limitations, we recorded local field potentials (LFPs) directly from the amygdala, OFC and hippocampus simultaneously in human male and female epilepsy patients performing a monetary incentive delay (MID) task. This allowed us to dissociate electrophysiological activity and connectivity patterns related to the anticipation and receipt of rewards and losses in real time. Anticipation of reward increased high-frequency gamma (HFG; 60-250 Hz) activity in the hippocampus and theta band (4-8 Hz) synchronization between amygdala and OFC, suggesting roles in memory and motivation. During receipt, HFG in the amygdala was involved in outcome value coding, the OFC cue context-specific outcome value comparison and the hippocampus reward coding. Receipt of loss decreased amygdala-hippocampus theta and increased amygdala-OFC HFG amplitude coupling which coincided with subsequent adjustments in behavior. Increased HFG synchronization between the amygdala and hippocampus during reward receipt suggested encoding of reward information into memory for reinstatement during anticipation. These findings extend what is known about the primate brain to humans, showing key spectrotemporal coding and communication dynamics for reward and punishment related processes which could serve as more precise targets for neuromodulation to establish causality and potential therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.