Evidence map›Paper›PMID 35148936›Full record

ArticleJournal of diabetes and its complications2022

Newly diagnosed diabetes vs. pre-existing diabetes upon admission for COVID-19: Associated factors, short-term outcomes, and long-term glycemic phenotypes.

Sara J Cromer, Caitlin Colling, Daria Schatoff, Michael Leary, Maria I Stamou, Daryl J Selen, Melissa S Putman, Deborah J Wexler

Open access · greenAbstract read
In one paragraph

Article in Journal of diabetes and its complications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic Review.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. The prognostic significance of insulin resistance in COVID-19: a review.Journal of diabetes and metabolic disorders · 2024
    Review
  11. Hospital Mortality and Morbidity in Diabetic Patients with COVID-19: A Retrospective Analysis from the UAE.International journal of environmental research and public health · 2024
    Article
  12. Review
  13. Observational
  14. New-Onset Diabetes After COVID-19.The Journal of clinical endocrinology and metabolism · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sara J CromerDivision of Endocrinology, Diabetes, and Metabolism, Massachusetts General Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address: scromer@mgh.harvard.edu.
Caitlin CollingDivision of Endocrinology, Diabetes, and Metabolism, Massachusetts General Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
Daria SchatoffDivision of Endocrinology, Diabetes, and Metabolism, Massachusetts General Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
Michael LearyFlorida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL, United States of America.
Maria I StamouDivision of Endocrinology, Diabetes, and Metabolism, Massachusetts General Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
Daryl J SelenDivision of Endocrinology, Diabetes, and Metabolism, Massachusetts General Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
Melissa S PutmanDivision of Endocrinology, Diabetes, and Metabolism, Massachusetts General Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America; Division of Endocrinology, Boston Children's Hospital, Boston, MA, United States of America.
Deborah J WexlerDivision of Endocrinology, Diabetes, and Metabolism, Massachusetts General Hospital, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.
Harvard University · USMassachusetts General Hospital · USFlorida Atlantic University · US

Funding

TRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5M
Clinical studies of a bionic pancreas for automated glucose management in cystic fibrosis-related diabetes mellitusR01DK119699 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI PUTMAN, MELISSA SUSAN · 2019 to 2024
$3.4M
Deciphering the Role of Copy Number Variants in Neuroendocrine Disorders of InfertilityF32HD108873 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI STAMOU, MARIA · 2022 to 2024
$233k
The Effect of Socioeconomic Status on Outcomes in Type 2 Diabetes Clinical TrialsF32DK127545 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CROMER, SARA JANE · 2020 to 2020
$76k
NICHD NIH HHS F32 HD108873NIDDK NIH HHS F32 DK127545NIDDK NIH HHS R01 DK119699NIDDK NIH HHS T32 DK007028
6 · The paper itself

Abstract

aimsHigh rates of newly diagnosed diabetes mellitus (NDDM) have been reported in association with coronavirus disease-2019 (COVID-19). Factors associated with NDDM and long-term glycemic outcomes are not known.

methodsRetrospective review of individuals admitted with COVID-19 and diabetes mellitus (DM; based on labs, diagnoses, outpatient insulin use, or severe inpatient hyperglycemia) between March and September 2020, with follow-up through July 2021.

resultsOf 1902 individuals admitted with COVID-19, 594 (31.2%) had DM; 77 (13.0%) of these had NDDM. Compared to pre-existing DM, NDDM was more common in younger patients and less common in those of non-Hispanic White race/ethnicity. Glycemic parameters were lower and inflammatory markers higher in patients with NDDM. In adjusted models, NDDM was associated with lower insulin requirements, longer length of stay, and intensive care unit admission but not death. Of 64 survivors with NDDM, 36 (56.3%) continued to have DM, 26 (40.6%) regressed to normoglycemia or pre-diabetes, and 2 were unable to be classified at a median follow-up of 323 days.

conclusionsDiabetes diagnosed at COVID-19 presentation is associated with lower glucose but higher inflammatory markers and ICU admission, suggesting stress hyperglycemia as a major physiologic mechanism. Approximately half of such individuals experience regression of DM.

Indexed as

COVID-19Diabetes MellitusHyperglycemiaBlood GlucoseHumansPhenotypeRetrospective StudiesBlood GlucoseCOVID-19Newly diagnosed diabetesStress hyperglycemia

Identifiers

PMID35148936
PMCPMC8813764
OpenAlexW4210438672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.