ArticleDevelopmental cell2022
Deceleration of the cell cycle underpins a switch from proliferative to terminal divisions in plant stomatal lineage.
Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- HOMEODOMAIN-LIKE shapes chromatin architecture and rewires leaf epidermal patterns.Nature communications · 2026Article
- Targets of SPEECHLESS and FAMA control guard cell division and expansion in the late stomatal lineage.Development (Cambridge, England) · 2026Article
- In Vitro Live Cell Imaging Reveals Nuclear Dynamics and Role of the Cytoskeleton During Asymmetric Division of Pollen Mitosis I in Nicotiana Benthamiana.Cytoskeleton (Hoboken, N.J.) · 2026Article
- Stomatal XVE: an inducible system for cell-stage-specific gene expression and editing in the stomatal lineage.The New phytologist · 2026Article
- MUTE drives asymmetric divisions to form stomatal subsidiary cells in Crassulaceae succulents.Science advances · 2026Article
- Cell cycle in plant development and reprogramming.Development (Cambridge, England) · 2026Review
- Multifaceted roles of SCRM/ICE1 in stomatal development, cold stress and beyond.Frontiers in plant science · 2026Review
- Do grasses have meristemoids?The New phytologist · 2025Article
- Warm temperature modifies cell fates to reduce stomata production in Arabidopsis.The New phytologist · 2025Article
- Guardians of Water and Gas Exchange: Adaptive Dynamics of Stomatal Development and Patterning.Plants (Basel, Switzerland) · 2025Review
- Confocal imaging of the cell cycle and cytokinin signaling during gynoecium development in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Article
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.Developmental cell · 2025Article
- A space for time. Exploring temporal regulation of plant development across spatial scales.The Plant journal : for cell and molecular biology · 2025Review
- Identification of Gene Targets for the Sprouting Inhibitor CIPC.Plant direct · 2025Article
- Regulation of cell cycle in plant gametes: when is the right time to divide?Development (Cambridge, England) · 2025Review
- The PEAPOD repressor complex in Arabidopsis stomatal development.Frontiers in plant science · 2025Review
- Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain.Nature communications · 2024Article
- Stomatal development in the changing climate.Development (Cambridge, England) · 2024Review
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.bioRxiv : the preprint server for biology · 2024Article
- What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated.Annual review of cell and developmental biology · 2024Review
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10 authors at 5 institutions in 3 countries.
Funding
Abstract
Differentiation of specialized cell types requires precise cell-cycle control. Plant stomata are generated through asymmetric divisions of a stem-cell-like precursor followed by a single symmetric division that creates paired guard cells surrounding a pore. The stomatal-lineage-specific transcription factor MUTE terminates the asymmetric divisions and commits to differentiation. However, the role of cell-cycle machineries in this transition remains unknown. We discover that the symmetric division is slower than the asymmetric division in Arabidopsis. We identify a plant-specific cyclin-dependent kinase inhibitor, SIAMESE-RELATED4 (SMR4), as a MUTE-induced molecular brake that decelerates the cell cycle. SMR4 physically and functionally associates with CYCD3;1 and extends the G1 phase of asymmetric divisions. By contrast, SMR4 fails to interact with CYCD5;1, a MUTE-induced G1 cyclin, and permits the symmetric division. Our work unravels a molecular framework of the proliferation-to-differentiation switch within the stomatal lineage and suggests that a timely proliferative cell cycle is critical for stomatal-lineage identity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.