Evidence map›Paper›PMID 35148814›Full record

ReviewCancer cell2022

Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy.

Michael P Vincent, Justin O Navidzadeh, Sharan Bobbala, Evan A Scott

Abstract readReview
In one paragraph

Review in Cancer cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
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  19. Article
  20. Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance.Combinatorial chemistry & high throughput screening · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael P VincentDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Justin O NavidzadehDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Sharan BobbalaDepartment of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, USA.
Evan A ScottDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Interdisciplinary Biological Sciences, Northwestern University, Evanston, IL 60208, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA; Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address: evan.scott@northwestern.edu.

Funding

Development of combination immunotherapies for atherosclerotic inflammationDP2HL132390 · NHLBI · NORTHWESTERN UNIVERSITY · PI SCOTT, EVAN ALEXANDER · 2015 to 2015
$2.3M
Visual Sciences T32T32EY025202 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Gregory William Schwartz · 2015 to 2026
$1.4M
NEI NIH HHS T32 EY025202NHLBI NIH HHS DP2 HL132390
6 · The paper itself

Abstract

Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics, biodistribution, and bioavailability. Here, nanotechnologies applied to cancer immunotherapy are discussed with a focus on current and next generation self-assembling drug delivery systems composed of lipids and/or polymers. Topics covered include the fundamental design, suitability, and inherent properties of nanomaterials that induce anti-tumor immune responses and support anti-cancer vaccination. Established active and passive targeting strategies as well as newer "indirect" methods are presented together with insights into how nanocarrier structure and surface chemistry can be leveraged for controlled delivery to the tumor microenvironment while minimizing off-target effects.

Indexed as

NanoparticlesNanostructuresNeoplasmsDrug Delivery SystemsHumansImmunotherapyTissue DistributionTumor Microenvironmentcancerdrug deliverynanomaterialtargetingtumor microenvironmentvaccine

Identifiers

PMID35148814
PMCPMC8930620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.