Evidence map›Paper›PMID 35148673›Full record

ArticleBMC immunology2022

Determining if T cell antigens are naturally processed and presented on HLA class I molecules.

Jay Friedman, Sreenivasulu Gunti, Maxwell Lee, Ke Bai, Christian Hinrichs, Clint T Allen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jay FriedmanSection on Translational Tumor Immunology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Room 7N240C, Bethesda, MD, 20892, USA.
Sreenivasulu GuntiSection on Translational Tumor Immunology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Room 7N240C, Bethesda, MD, 20892, USA.
Maxwell LeeSection on Translational Tumor Immunology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Room 7N240C, Bethesda, MD, 20892, USA.
Ke BaiSection on Translational Tumor Immunology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Room 7N240C, Bethesda, MD, 20892, USA.
Christian HinrichsRutgers Cancer Center at Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Clint T AllenSection on Translational Tumor Immunology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Room 7N240C, Bethesda, MD, 20892, USA. clint.allen@nih.gov.
National Institutes of Health · USNational Institute on Deafness and Other Communication Disorders · USRutgers, The State University of New Jersey · US

Funding

Characterization and Enhancement of Anti-Tumor Immune Responses in Head and Neck CancerZIADC000087 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI ALLEN, CLINT · 2015 to 2022
$13.5M
PSYCHOLOGICAL STUDIES OF BINAURAL HEARING AND ATTENTIONR01DC000087 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HAFTER, ERVIN R · 1989 to 2006
$2.3M
Intramural Research Program, NIDCD ZIA-DC000087NIDCD NIH HHS R01 DC000087
6 · The paper itself

Abstract

backgroundDetermining T cell responses to naturally processed and presented antigens is a critical immune correlate to determine efficacy of an investigational immunotherapeutic in clinical trials. In most cases, minimal epitopes and HLA restriction elements are unknown.

resultsHere, we detail the experimental use of ex vivo expanded autologous B cells as antigen presenting cells to overcome the limitation of unknown HLA restriction, and the use of electroporated full length mRNA encoding full length parental proteins to ensure that any observed T cell responses are specific for antigens that are naturally processed and presented.

conclusionsThis technique can serve as useful experimental approach to determine the induction or enhancement of specific responses to naturally processed and presented antigens on HLA class I molecules in peripheral blood or tumor infiltrating T cells.

Indexed as

Antigen PresentationAntigen-Presenting CellsAntigens, NeoplasmB-LymphocytesEpitopesEpitopes, T-LymphocyteT-LymphocytesAntigens, NeoplasmEpitopesEpitopes, T-LymphocyteAntigen presenting cellsElectroporationHLA restrictionMinimal epitopeT cell responses

Identifiers

PMID35148673
PMCPMC8832792
OpenAlexW4211174366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.