Evidence map›Paper›PMID 35148670›Full record

ArticleBioengineered2022

Magnetic resonance imaging features of hippocampus and mechanism of neurocognitive dysfunction for antiepileptic drugs in treatment of depression rats.

Tuxiu Xie, Ran Li, Xiaobing Long, Jun Chen, Lu Ye, Jing Wang, Guijun Jiang, Jingjun Lv

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tuxiu XieDepartment of General Practice, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Ran LiSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei Province, China.
Xiaobing LongDepartment of Emergency, the Center of Emergency and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Jun ChenDepartment of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Lu YeDepartment of Emergency, the Center of Emergency and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Jing WangDepartment of Emergency, the Center of Emergency and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Guijun JiangDepartment of Emergency, the Center of Emergency and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Jingjun LvDepartment of Emergency, the Center of Emergency and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Wuhan University · CNNorth China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the effects of antiepileptic drug sodium valproate on magnetic resonance imaging (MRI) images, neurological cognition, and JAK1/STAT3 pathway in hippocampus of rats with depression, 30 Sprague Dawley (SD) rats were included. The depression model (DM) was prepared through the chronic stress restraint test. Some model rats were injected with 10 mg/kg sodium valproate into abdominal cavity before modeling (RT group)), and healthy rats were selected as controls (healthy control (HC) group). Depth of split brain was greatly increased in DM group, and nitrogen-acetyl aspartic acid (NAA)/creatine (Cr), glutamic acid (Glu)/Cr, and choline (Cho)/Cr ratios were greatly reduced (

Indexed as

AnticonvulsantsDepressionAnimalsAspartic AcidCreatineHippocampusMagnetic Resonance ImagingRatsRats, Sprague-DawleyValproic AcidAnticonvulsantsAspartic AcidCreatineValproic Acidcognitive functioninflammatory factorsJAK1/STAT3 pathwaymagnetic resonance imaging imagesneurometabolitesSodium valproate

Identifiers

PMID35148670
PMCPMC8973768
OpenAlexW4211110075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.