ArticlePlant physiology2022
Brassinosteroid-regulated bHLH transcription factor CESTA induces the gibberellin 2-oxidase GA2ox7.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Artificial Selection on theInternational journal of molecular sciences · 2026Article
- Transcription factor MdWRKY50 correlates with spur-type formation in apple by modulating endogenous gibberellin biosynthesis.BMC plant biology · 2025Article
- Integrated endogenous hormones and transcriptome analysis contribute to fruit development related gene mining in Eriobotrya japonica.Scientific reports · 2025Article
- Plant Coping with Cold Stress: Molecular and Physiological Adaptive Mechanisms with Future Perspectives.Cells · 2025Review
- Increased brassinolide accumulation and increased growth in low-light-grown transgenic tobacco.Photosynthetica · 2025Article
- The regulatory role of ZmSTOMAGEN1/2 in maize stomatal development is elucidated via gene editing and metabolic profiling.PloS one · 2025Article
- SlUPA-like, a bHLH Transcription Factor in Tomato (International journal of molecular sciences · 2024Article
- GIBBERELLIN PERCEPTION SENSOR 2 reveals genesis and role of cellular GA dynamics in light-regulated hypocotyl growth.The Plant cell · 2024Article
- Integrating QTL mapping and transcriptomics to decipher the genetic architecture of sterol metabolism inHorticulture research · 2024Article
- Basic helix-loop-helix (bHLH) gene family in rye (Secale cereale L.): genome-wide identification, phylogeny, evolutionary expansion and expression analyses.BMC genomics · 2024Article
- Plant Adaptation to Flooding Stress under Changing Climate Conditions: Ongoing Breakthroughs and Future Challenges.Plants (Basel, Switzerland) · 2023Review
- Fine-tuned nitric oxide and hormone interface in plant root development and regeneration.Journal of experimental botany · 2023Review
- AcbHLH144 transcription factor negatively regulates phenolic biosynthesis to modulate pineapple internal browning.Horticulture research · 2023Article
- The Role of Light Quality in Regulating Early Seedling Development.Plants (Basel, Switzerland) · 2023Review
- Identification ofPlants (Basel, Switzerland) · 2023Article
- Article
- SlCESTA Is a Brassinosteroid-Regulated bHLH Transcription Factor of Tomato That Promotes Chilling Tolerance and Fruit Growth When Over-Expressed.Frontiers in plant science · 2022Article
- Species-Specific Variation in Abscisic Acid Homeostasis and Responses Impacts Important Traits inFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brassinosteroids (BRs) are plant steroids that have growth-promoting capacities, which are partly enabled by an ability to induce biosynthesis of gibberellins (GAs), a second class of plant hormones. In addition, BRs can also activate GA catabolism; here we show that in Arabidopsis (Arabidopsis thaliana) the basic helix-loop-helix transcription factor CESTA (CES) and its homologues BRASSINOSTEROID-ENHANCED EXPRESSION (BEE) 1 and 3 contribute to this activity. CES and the BEEs are BR-regulated at the transcriptional and posttranslational level and participate in different physiological processes, including vegetative and reproduction development, shade avoidance, and cold stress responses. We show that CES/BEEs can induce the expression of the class III GA 2-oxidase GA2ox7 and that this activity is increased by BRs. In BR signaling - and CES/BEE-deficient mutants, GA2ox7 expression decreased, yielding reduced levels of GA110, a product of GA2ox7 activity. In plants that over-express CES, GA2ox7 expression is hyper-responsive to BR, GA110 levels are elevated and amounts of bioactive GA are reduced. We provide evidence that CES directly binds to the GA2ox7 promoter and is activated by BRs, but can also act by BR-independent means. Based on these results, we propose a model for CES activity in GA catabolism where CES can be recruited for GA2ox7 induction not only by BR, but also by other factors.
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Registered trials
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