ArticleBiomedical journal2022
High levels estradiol affect blastocyst implantation and post-implantation development directly in mice.
Article in Biomedical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Follicular kisspeptin-VEGF axis in polycystic ovary syndrome and ovarian hyperstimulation syndrome.Journal of assisted reproduction and genetics · 2026Article
- The threshold of estradiol level for fresh embryo transfer differs between blastocyst and cleavage-stage embryo.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Association of estradiol and progesterone levels on human chorionic gonadotropin day with pregnancy outcomes in IVF/ICSI fresh embryo transfer.Frontiers in endocrinology · 2026Article
- Effect of hCG day's estradiol levels on pregnancy outcomes following GnRH antagonist protocol: a retrospective study of 3192 fresh embryo transfer cycles.BMC pregnancy and childbirth · 2025Article
- The deleterious effect of bisphenol S on early embryo development of mice.Hormones (Athens, Greece) · 2025Article
- Relationship Between Estradiol Levels Measured on the Initiation Day of GnRH Antagonist Treatment and Pregnancy Outcomes in Patients Receiving the Antagonist Protocol.Medicina (Kaunas, Lithuania) · 2025Article
- Development and externally validated prediction model of individualization of FSH starting dose in the depot GnRH agonist protocol for the early follicular phase.Frontiers in endocrinology · 2025Article
- Linking the Warburg effect to endometrial receptivity: metabolic parallels in embryo implantation.Frontiers in cell and developmental biology · 2025Review
- High serum progesterone levels on the day of embryo transfer in patients undergoing artificial frozen-thawed blastocyst transfer: Is there a ceiling effect?Turkish journal of obstetrics and gynecology · 2024Article
- The benefits of flushing with Lemuru fish oil as a source of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on the performance of reproductive parameters in Garut ewes.Tropical animal health and production · 2024Article
- Clinical outcomes of fresh and frozen embryos transfer afterZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Article
- Pluripotency-independent induction of human trophoblast stem cells from fibroblasts.Nature communications · 2023Article
- Association of Polymorphisms inBiomedicines · 2023Article
- Effect of the ratios of estradiol increase on the outcome of in vitro fertilization-embryo transfer with antagonist regimens: a single center retrospective cohort study.BMC pregnancy and childbirth · 2023Article
- Heterotopic pregnancy after assisted reproductive techniques with favorable outcome of the intrauterine pregnancy: A case report.World journal of clinical cases · 2023Article
- Article
- About gladiators and a sacred disease.Biomedical journal · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have demonstrated that high levels of estradiol (E2) impair blastocyst implantation through effects on the endometrium; however, whether high E2 directly affects blastocysts is not well established. The present study sought to clarify the direct impacts of high E2 levels on blastocysts in vitro.
methodsICR virgin albino mice were used. Using an in-vitro 8-day blastocyst culture model, immunofluorescence staining for the estrogen receptor (ER), blastocyst outgrowth assays, differential staining and TUNEL assays of blastocysts, and embryo transfer, we investigated the main outcomes of exposure to different E2 concentrations (10
resultsERα and ERβ expression were detected in pre-implantation stage embryos. In vitro exposure of blastocysts to 10
conclusionExposure to high E2 concentrations in vitro is deleterious to blastocyst implantation and early post-implantation development, mainly owing to direct impacts of E2 on implanting blastocysts. In clinical assisted reproductive technique (ART), high serum E2 concentrations not only affects the endometrium, but also affects blastocysts directly at the period of implantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.